J
Joseph T. Shieh
Researcher at University of California, San Francisco
Publications - 94
Citations - 3616
Joseph T. Shieh is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Exome sequencing & Gene. The author has an hindex of 25, co-authored 85 publications receiving 2861 citations. Previous affiliations of Joseph T. Shieh include University of Pennsylvania & Children's Hospital of Philadelphia.
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Journal ArticleDOI
The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction.
Christopher J. Cohen,Joseph T. Shieh,Raymond J. Pickles,Takatsugu Okegawa,Jer Tsong Hsieh,Jeffrey M. Bergelson +5 more
TL;DR: Results indicate that CAR is a component of the tight junction and of the functional barrier to paracellular solute movement and thatquestration of CAR in tight junctions may limit virus infection across epithelial surfaces.
Journal ArticleDOI
Microglia Express CCR5, CXCR4, and CCR3, but of These, CCR5 Is the Principal Coreceptor for Human Immunodeficiency Virus Type 1 Dementia Isolates
Andrew V. Albright,Joseph T. Shieh,Takayuki Itoh,Benhur Lee,David E Pleasure,Michael J. O'Connor,Robert W. Doms,Francisco Gonzalez-Scarano +7 more
TL;DR: It is found that virus pseudotyped with the DS-br and RC-br envelopes can infect cells transfected with CD4 in conjunction with the G-protein-coupled receptors APJ, CCR8, and GPR15, which have been previously implicated in HIV entry.
Journal ArticleDOI
Newborn Sequencing in Genomic Medicine and Public Health.
Jonathan S. Berg,Pankaj B. Agrawal,Donald B. Bailey,Alan H. Beggs,Steven E. Brenner,Amy Brower,Julie A. Cakici,Ozge Ceyhan-Birsoy,Kee Chan,Flavia Chen,Robert Currier,Dmitry Dukhovny,Robert C. Green,Julie Harris-Wai,Ingrid A. Holm,Brenda Iglesias,Galen Joseph,Stephen F. Kingsmore,Barbara A. Koenig,Pui-Yan Kwok,John D. Lantos,Steven J. Leeder,Megan A. Lewis,Amy L. McGuire,Laura V. Milko,Sean D. Mooney,Richard B. Parad,Stacey Pereira,Joshua E. Petrikin,Bradford C. Powell,Cynthia M. Powell,Jennifer M. Puck,Heidi L. Rehm,Neil Risch,Myra I. Roche,Joseph T. Shieh,Narayanan Veeraraghavan,Michael S. Watson,Laurel K. Willig,Timothy W. Yu,Tiina K. Urv,Anastasia L. Wise +41 more
TL;DR: An overview of the Newborn Sequencing in Genomic Medicine and Public Health Consortium is provided, which is investigating the application of genome-scale sequencing in newborns for both diagnosis and screening.
Journal ArticleDOI
Clinical and molecular features of mitochondrial DNA depletion due to mutations in deoxyguanosine kinase.
David Dimmock,Qing Zhang,Carlo Dionisi-Vici,Rosalba Carrozzo,Joseph T. Shieh,Lin-Ya Tang,Cavatina K. Truong,Eric S. Schmitt,Mara Sifry-Platt,Simona Lucioli,Filippo M. Santorelli,Can Ficicioglu,M. Rodriguez,Klaas J. Wierenga,Gregory M. Enns,Nicola Longo,Mark H. Lipson,Hilary Vallance,William J. Craigen,Fernando Scaglia,L.-J. Wong +20 more
TL;DR: The presentation of one case with apparent viral hepatitis, without neurological disease, suggests that this disease should be considered in patients with infantile liver failure regardless of the presence of neurological features or apparent infectious etiology.
Journal ArticleDOI
Elevated miR-499 levels blunt the cardiac stress response.
TL;DR: It is found that elevated miR-499 levels caused cellular hypertrophy and cardiac dysfunction in a dose-dependent manner and may titrate the cardiac response to stress in part by regulating the immediate early gene response.