J
Joseph Therriault
Researcher at McGill University
Publications - 110
Citations - 2342
Joseph Therriault is an academic researcher from McGill University. The author has contributed to research in topics: Medicine & Disease. The author has an hindex of 13, co-authored 48 publications receiving 926 citations. Previous affiliations of Joseph Therriault include Douglas Mental Health University Institute & Montreal Neurological Institute and Hospital.
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Journal ArticleDOI
Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts.
Thomas K. Karikari,Tharick A. Pascoal,Tharick A. Pascoal,Nicholas J. Ashton,Shorena Janelidze,Andrea Lessa Benedet,Juan Lantero Rodriguez,Mira Chamoun,Melissa Savard,Min Su Kang,Min Su Kang,Joseph Therriault,Michael Schöll,Gassan Massarweh,Jean-Paul Soucy,Kina Höglund,Kina Höglund,Gunnar Brinkmalm,Niklas Mattsson,Sebastian Palmqvist,Serge Gauthier,Erik Stomrud,Henrik Zetterberg,Henrik Zetterberg,Henrik Zetterberg,Oskar Hansson,Pedro Rosa-Neto,Pedro Rosa-Neto,Kaj Blennow,Kaj Blennow +29 more
TL;DR: Blood p-tau181 can predict tau and amyloid β pathologies, differentiate Alzheimer's disease from other neurodegenerative disorders, and identify Alzheimer's Disease across the clinical continuum.
Journal ArticleDOI
Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain
Kok Pin Ng,Tharick A. Pascoal,Sulantha Mathotaarachchi,Joseph Therriault,Min Su Kang,Monica Shin,Marie-Christine Guiot,Qi Guo,Ryuichi Harada,Robert A. Comley,Gassan Massarweh,Jean-Paul Soucy,Nobuyuki Okamura,Serge Gauthier,Pedro Rosa-Neto +14 more
TL;DR: The results indicate that the interpretation of 18F-THK5351 PET images, with respect to tau, is confounded by the high MAO-B availability across the entire brain.
Journal ArticleDOI
Microglial activation and tau propagate jointly across Braak stages
Tharick A. Pascoal,Andrea Lessa Benedet,Nicholas J. Ashton,Nicholas J. Ashton,Nicholas J. Ashton,Min Su Kang,Min Su Kang,Joseph Therriault,Mira Chamoun,Melissa Savard,Firoza Z. Lussier,Cecile Tissot,Thomas K. Karikari,Julie Ottoy,Julie Ottoy,Sulantha Mathotaarachchi,Jenna Stevenson,Gassan Massarweh,Michael Schöll,Michael Schöll,Mony J. de Leon,Jean-Paul Soucy,Paul Edison,Kaj Blennow,Kaj Blennow,Henrik Zetterberg,Serge Gauthier,Pedro Rosa-Neto,Pedro Rosa-Neto +28 more
TL;DR: In this paper, the spatial propagation of microglial activation and tau accumulation colocalize in a Braak-like pattern in the living human brain, suggesting an interaction that determines disease progression.
Journal ArticleDOI
Association of Apolipoprotein E ε4 With Medial Temporal Tau Independent of Amyloid-β.
Joseph Therriault,Joseph Therriault,Andrea Lessa Benedet,Andrea Lessa Benedet,Tharick A. Pascoal,Tharick A. Pascoal,Sulantha Mathotaarachchi,Mira Chamoun,Melissa Savard,Emilie Thomas,Min Su Kang,Min Su Kang,Firoza Z. Lussier,Firoza Z. Lussier,Cecile Tissot,Cecile Tissot,Marlee Parsons,Marlee Parsons,Muhammad Naveed Iqbal Qureshi,Paolo Vitali,Gassan Massarweh,Gassan Massarweh,Jean-Paul Soucy,Jean-Paul Soucy,Soham Rej,Paramita Saha-Chaudhuri,Serge Gauthier,Pedro Rosa-Neto +27 more
TL;DR: In both cohorts, APOEε4 was associated in increased tau-PET uptake in the entorhinal cortex and hippocampus independently of amyloid-β, sex, age, and clinical status after multiple comparisons correction, contributing to an evolving framework in which APoeε4 has deleterious consequences in Alzheimer disease beyond its link with amyloids-β.
Journal ArticleDOI
18F-MK-6240 PET for early and late detection of neurofibrillary tangles.
Tharick A. Pascoal,Joseph Therriault,Andrea Lessa Benedet,Melissa Savard,Firoza Z. Lussier,Mira Chamoun,Cecile Tissot,Muhammad Naveed Iqbal Qureshi,Min Su Kang,Sulantha Mathotaarachchi,Jenna Stevenson,Robert Hopewell,Gassan Massarweh,Jean-Paul Soucy,Serge Gauthier,Pedro Rosa-Neto +15 more
TL;DR: The results suggest that the hierarchical six-stage Braak model using 18F-MK-6240 imaging provides an index of early and late tau accumulation as well as disease stage in preclinical and symptomatic individuals.