J
Josephine Hoh
Researcher at Yale University
Publications - 79
Citations - 16417
Josephine Hoh is an academic researcher from Yale University. The author has contributed to research in topics: Single-nucleotide polymorphism & Macular degeneration. The author has an hindex of 35, co-authored 78 publications receiving 15592 citations. Previous affiliations of Josephine Hoh include Rockefeller University.
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Journal ArticleDOI
Complement Factor H Polymorphism in Age-Related Macular Degeneration
Robert J. Klein,Caroline J. Zeiss,Emily Y. Chew,Jen-yue Tsai,Richard S. Sackler,Chad Haynes,A. K. Henning,John Paul SanGiovanni,Shrikant Mane,Susan T. Mayne,Michael B. Bracken,Frederick L. Ferris,Jurg Ott,Colin J. Barnstable,Josephine Hoh +14 more
TL;DR: A genome-wide screen for polymorphisms associated with age-related macular degeneration revealed a polymorphism in linkage disequilibrium with the risk allele representing a tyrosine-histidine change at amino acid 402 in the complement factor H gene.
Journal ArticleDOI
Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression: A Meta-analysis
Neil Risch,Richard Herrell,Thomas Lehner,Kung Yee Liang,Lindon J. Eaves,Josephine Hoh,Andrea Griem,Maria Kovacs,Jurg Ott,Kathleen R. Merikangas +9 more
TL;DR: This meta-analysis yielded no evidence that the serotonin transporter genotype alone or in interaction with stressful life events is associated with an elevated risk of depression in men alone, women alone, or in both sexes combined.
Journal ArticleDOI
Complement factor H polymorphism in age-related macular degeneration
Robert J. Klein,C. Zeiss,Emily Y. Chew,J.Y. Tsai,Richard S. Sackler,Chad Haynes,A. K. Henning,John Paul SanGiovanni,S.M. Manne,S.T. Mayne,Michael B. Bracken,Frederick L. Ferris,Jurg Ott,Colin J. Barnstable,Josephine Hoh +14 more
TL;DR: A genome-wide screen for polymorphisms associated with age-related macular degeneration revealed a polymorphism in linkage disequilibrium with the risk allele representing a tyrosine-histidine change at amino acid 402 in the complement factor H gene.
Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression
Neil Risch,Richard Herrell,Thomas Lehner,Kung-Yee Liang,Lindon J. Eaves,Josephine Hoh,Andrea Griem,Maria Kovacs,Jurg Ott,Kathleen R. Merikangas +9 more
TL;DR: Merikangas et al. as discussed by the authors showed that most common genetic risks, at least when studied individually, are modest in magnitude, with relative risks in the range of 1.3 or less.
Journal ArticleDOI
Replicating genotype–phenotype associations
Stephen J. Chanock,Teri A. Manolio,Michael Boehnke,Eric Boerwinkle,David J. Hunter,Gilles Thomas,Joel N. Hirschhorn,Gonçalo R. Abecasis,David Altshuler,Joan E. Bailey-Wilson,Lisa D. Brooks,Lon R. Cardon,Mark J. Daly,Peter Donnelly,Joseph F. Fraumeni,Nelson B. Freimer,Daniela S. Gerhard,Chris Gunter,Alan E. Guttmacher,Mark S. Guyer,Emily L. Harris,Josephine Hoh,Robert N. Hoover,C. Augustine Kong,Kathleen R. Merikangas,Cynthia C. Morton,Lyle J. Palmer,Elizabeth G. Phimister,John P. Rice,Jerry Roberts,Charles N. Rotimi,Margaret A. Tucker,Kyle Vogan,Sholom Wacholder,Ellen M. Wijsman,Deborah M. Winn,Francis S. Collins +36 more
TL;DR: What constitutes replication of a genotype–phenotype association, and how best can it be achieved, is investigated.