J
Josephine Lum
Researcher at Agency for Science, Technology and Research
Publications - 9
Citations - 1873
Josephine Lum is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: MRNA Sequencing & Population. The author has an hindex of 7, co-authored 9 publications receiving 1138 citations. Previous affiliations of Josephine Lum include Singapore Immunology Network.
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Journal ArticleDOI
Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches
Svetoslav Chakarov,Hwee Ying Lim,Leonard Tan,Sheau Yng Lim,Peter See,Josephine Lum,Xiao Meng Zhang,Shihui Foo,Satoshi Nakamizo,Kaibo Duan,Wan Ting Kong,Rebecca Gentek,Akhila Balachander,Daniel Carbajo,Camille Bleriot,Benoit Malleret,Benoit Malleret,John Kit Chung Tam,Sonia Baig,Muhammad Shabeer,Sue-Anne Ee Shiow Toh,Andreas Schlitzer,Anis Larbi,Thomas Marichal,Bernard Malissen,Jinmiao Chen,Michael Poidinger,Kenji Kabashima,Kenji Kabashima,Marc Bajénoff,Lai Guan Ng,Veronique Angeli,Florent Ginhoux +32 more
TL;DR: In this article, two independent resident tissue macrophages (RTMs) populations are identified across tissues with specific niche-dependent phenotype and functional programming, and they are slowly replaced by Ly6Chi monocytes.
Journal ArticleDOI
Mapping the human DC lineage through the integration of high-dimensional techniques
Peter See,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Jinmiao Chen,Patrick Günther,Naomi McGovern,Sergio Erdal Irac,Merry Gunawan,Marc Beyer,Marc Beyer,Kristian Händler,Kaibo Duan,Hermi Sumatoh,Nicolas Ruffin,Mabel Jouve,Ester Gea-Mallorquí,Raoul C.M. Hennekam,Tony Kiat Hon Lim,Chan Chung Yip,Ming Wen,Benoit Malleret,Benoit Malleret,Ivy Low,Nurhidaya Binte Shadan,Charlene Foong Shu Fen,Alicia Tay,Josephine Lum,Francesca Zolezzi,Anis Larbi,Michael Poidinger,Jerry Kok Yen Chan,Qingfeng Chen,Laurent Rénia,Muzlifah Haniffa,Philippe Benaroch,Andreas Schlitzer,Andreas Schlitzer,Joachim L. Schultze,Joachim L. Schultze,Evan W. Newell,Florent Ginhoux +40 more
TL;DR: Two unbiased high-dimensional technologies are employed to characterize the human DC lineage from bone marrow to blood and provide new markers that can be used to identify unambiguously pre-DC from pDC, including CD33, CX3CR1, CD2, CD5, and CD327.
Journal Article
Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches
Svetoslav Chakarov,Hwee Ying Lim,Leonard Tan,Sheau Yng Lim,Peter See,Josephine Lum,Xiao Meng Zhang,Shihui Foo,Satoshi Nakamizo,Kaibo Duan,Wan Ting Kong,Rebecca Gentek,Akhila Balachander,Daniel Carbajo,Camille Bleriot,Benoit Malleret,John Kit Chung Tam,Sonia Baig,Muhammad Shabeer,Sue-Anne Ee Shiow Toh,Andreas Schlitzer,Anis Larbi,Thomas Marichal,Bernard Malissen,Jinmiao Chen,Michael Poidinger,Kenji Kabashima,Marc Bajénoff,Lai Guan Ng,Veronique Angeli,Florent Ginhoux +30 more
TL;DR: Two independent MRTMs populations exist across tissues with specific niche-dependent phenotype and functional programming, and it is shown that monocyte-derived RTMs (MRTMs) are two separate lineages, rather than representing points along a developmental or maturation continuum.
Journal ArticleDOI
Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells.
Charles-Antoine Dutertre,Charles-Antoine Dutertre,Etienne Becht,Sergio Erdal Irac,Sergio Erdal Irac,Ahad Khalilnezhad,Ahad Khalilnezhad,Vipin Narang,Shabnam Khalilnezhad,Pei Y. Ng,Lucas L van den Hoogen,Jing Yao Leong,Bernett Lee,Marion Chevrier,Xiao Meng Zhang,Pearly Yong,Geraldine Koh,Josephine Lum,Shanshan W. Howland,Esther Wing Hei Mok,Jinmiao Chen,Anis Larbi,Henry K.K. Tan,Tony Kiat Hon Lim,Panagiota Karagianni,Athanasios G. Tzioufas,Benoit Malleret,Benoit Malleret,Joshua Brody,Salvatore Albani,Joel A G van Roon,Timothy R D J Radstake,Evan W. Newell,Florent Ginhoux,Florent Ginhoux +34 more
TL;DR: High-dimensional single-cell protein and RNA expression data is integrated to identify distinct markers to delineate monocytes from conventional DC2 (cDC2s), further unravel the heterogeneity of DC subpopulations in health and disease and may pave the way for the identification of specific DC subset-targeting therapies.
Journal ArticleDOI
Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2
Naomi McGovern,Amanda Shin,Amanda Shin,Gillian Low,Donovan Low,Kaibo Duan,Leong Jing Yao,Rasha Msallam,Ivy Low,Nurhidaya Binte Shadan,Hermi Sumatoh,Erin Soon,Josephine Lum,Esther Wing Hei Mok,Sandra Hubert,Peter See,Edwin Huang Kunxiang,Yie Hou Lee,Yie Hou Lee,Baptiste Janela,Mahesh Choolani,Citra Nurfarah Zaini Mattar,Yiping Fan,Yiping Fan,Tony Kiat Hon Lim,Dedrick Kok Hong Chan,Ker-Kan Tan,Ker-Kan Tan,John Kit Chung Tam,Christopher Schuster,Adelheid Elbe-Bürger,Xiao-Nong Wang,Venetia Bigley,Matthew Collin,Muzlifah Haniffa,Andreas Schlitzer,Andreas Schlitzer,Andreas Schlitzer,Michael Poidinger,Salvatore Albani,Anis Larbi,Evan W. Newell,Jerry Kok Yen Chan,Florent Ginhoux +43 more
TL;DR: The results reveal a previously unappreciated role of dendritic cells within the developing fetus and indicate that they mediate homeostatic immune-suppressive responses during gestation.