Joshua R. Corbin

TL;DR: Successful applications of a variety of design principles to tunable, Ag-catalyzed aminations are described, including changing Ag/ligand ratios to influence chemoselectivity, manipulating the steric environment of the catalyst to achieve site-selective C-H bond amination, and promoting noncovalent interactions between Ag/substrate or substrate/ligands to direct C-h functionalization.

TL;DR: X-ray structural characterizations were helpful in determining ligand features that promote the formation of monomeric versus dimeric complexes, and Variable-temperature 1H and DOSY NMR experiments were especially useful for understanding how the ligand identity influences the nuclearity, coordination number, and fluxional behavior of silver(I) complexes in solution.

TL;DR: Investigations into tunable and site-selective nitrene transfers between tertiary C(sp3)-H bonds using a combination of transition metal catalysts, including complexes based on Ag, Mn, Rh and Ru show the ability to reverse the selectivity of nitrene transfer by a simple change in the identity of the N-donor ligand supporting the Ag(i) complex.

TL;DR: The first examples of site- and chemoselective CH bond amination reactions in aqueous media with the unexpected ability to employ water as the solvent in these reactions are reported.

TL;DR: A bio-inspired, strain-driven ring opening of bicyclic methyleneaziridines to 2-amidopentadienyl cation intermediates that readily engage in Nazarov cyclizations is disclosed, providing a framework for the future development of asymmetric 2-imino-Nazarov cyclizations.