J
Joshua S. Wahlstrom
Researcher at University of Chicago
Publications - 4
Citations - 166
Joshua S. Wahlstrom is an academic researcher from University of Chicago. The author has contributed to research in topics: DNA damage & Phosphorylation. The author has an hindex of 4, co-authored 4 publications receiving 133 citations.
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Journal ArticleDOI
Loss of Nfkb1 leads to early onset aging
Giovanna M. Bernal,Joshua S. Wahlstrom,Clayton D. Crawley,Kirk E. Cahill,Peter Pytel,Hua Liang,Shijun Kang,Ralph R. Weichselbaum,Bakhtiar Yamini +8 more
TL;DR: Data show that loss of Nfkb1 leads to early animal aging that is associated with reduced apoptosis and increased cellular senescence, and support the strong link between the NF-(B pathway and mammalian aging.
Journal ArticleDOI
p50 (NF-κB1) Is an Effector Protein in the Cytotoxic Response to DNA Methylation Damage
Adam M. Schmitt,Clayton D. Crawley,Shijune Kang,David R. Raleigh,Xiaohong Yu,Joshua S. Wahlstrom,David J. Voce,Thomas E. Darga,Ralph R. Weichselbaum,Bakhtiar Yamini +9 more
TL;DR: The p50 subunit of NF-κB is identified as a central target in the response to O(6)-MeG and it is demonstrated that p50 is required for S(N)1-methylator-induced cytotoxicity.
Journal ArticleDOI
Nfkb1 is a haploinsufficient DNA damage-specific tumor suppressor
David J. Voce,Adam M. Schmitt,Abhineet Uppal,Megan E. McNerney,Giovanna M. Bernal,Kirk E. Cahill,Joshua S. Wahlstrom,Ashley M. Nassiri,Xiaohong Yu,Clayton D. Crawley,Kevin P. White,Kenan Onel,Ralph R. Weichselbaum,Bakhtiar Yamini +13 more
TL;DR: Analysis of human cancers, including therapy-related myeloid neoplasms, demonstrates that NFKB1 mRNA expression is downregulated compared with control samples in multiple hematological malignancies, indicating that Nfkb1 is a haploinsufficient, pathway-specific tumor suppressor that prevents the development of hematologic malignancy in the setting of alkylation damage.
Journal ArticleDOI
S-phase-dependent p50/NF-кB1 phosphorylation in response to ATR and replication stress acts to maintain genomic stability
Clayton D. Crawley,Shijun Kang,Giovanna M. Bernal,Joshua S. Wahlstrom,David J. Voce,Kirk E. Cahill,Andrea Garofalo,David R. Raleigh,Ralph R. Weichselbaum,Bakhtiar Yamini +9 more
TL;DR: It is shown that ATR directly reduces survival by inducing phosphorylation of the p50 (NF-κB1, p105) subunit of NF-кB and moreover, that this response is necessary for genome maintenance independent of checkpoint activity.