J
Jouko Savolainen
Researcher at University of Eastern Finland
Publications - 34
Citations - 2634
Jouko Savolainen is an academic researcher from University of Eastern Finland. The author has contributed to research in topics: Prodrug & Entacapone. The author has an hindex of 18, co-authored 34 publications receiving 2367 citations. Previous affiliations of Jouko Savolainen include Park University.
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Journal ArticleDOI
Prodrugs: design and clinical applications
Jarkko Rautio,Hanna Kumpulainen,Tycho Heimbach,Reza Oliyai,Doo-Man Oh,Tomi Järvinen,Jouko Savolainen +6 more
TL;DR: The most common functional groups that are amenable to prodrug design are described, and examples of prodrugs that are either launched or are undergoing human trials are highlighted.
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Large Neutral Amino Acid Transporter Enables Brain Drug Delivery via Prodrugs
Mikko Gynther,Krista Laine,Jarmo Ropponen,Jukka Leppänen,Anne Mannila,Tapio Nevalainen,Jouko Savolainen,Tomi Järvinen,Jarkko Rautio +8 more
TL;DR: The results reveal for the first time that a drug-substrate conjugate is able to transport drugs into the brain via LAT1, and a specific LAT1 inhibitor significantly decreased the brain uptake of the prodrug.
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Prodrug approaches for CNS delivery.
TL;DR: Insight is provided into various prodrug strategies explored to date for CNS drug delivery, including lipophilic prodrugs, carrier- and receptor-mediated prodrug delivery systems, and gene-directed enzyme prodrug therapy.
Journal ArticleDOI
Paracetamol (acetaminophen) penetrates readily into the cerebrospinal fluid of children after intravenous administration
TL;DR: Paracetamol permeates readily into the cerebrospinal fluid of children, which enables the rapid central analgesic and antipyretic action of intravenous par acetamol.
Journal ArticleDOI
Co-administration of a water-soluble polymer increases the usefulness of cyclodextrins in solid oral dosage forms.
Jouko Savolainen,Kristiina Järvinen,Hannu Taipale,Pekka Jarho,Thorsteinn Loftsson,Tomi Järvinen +5 more
TL;DR: The pharmaceutical usefulness of cyclodextrins in oral administration may be substantially improved by co-administration of a water-soluble polymer.