Joyce Taylor-Papadimitriou

TL;DR: The full sequence for PEM, as deduced from cDNA sequences, is reported, with length variations in the tandem repeat result in PEM being an expressed variable number tandem repeat locus.

TL;DR: Three hybridomas producing monoclonal antibodies (IgG), reacting with components of the human mammary milk fat globule have been isolated and show negative reactions with fibroblasts, lymphoblastoid cells, and a large number of epithelial cell lines of non‐breast origin.

TL;DR: It is shown here that all three antibodies react with a synthetic peptide with an amino acid sequence corresponding to that predicted by the tandem repeat, allowing a directed approach to the development of tumor-specific antibodies using synthetic peptides as immunogens.

TL;DR: It appears that this monoclonal antibody is reacting with an epitope that is usually masked by oligosaccharide moieties in normal cells but which is exposed, perhaps due to aberrant glycosylation, in malignant cells.

TL;DR: PLU-1, a transcriptional repressor implicated in breast cancer, is identified as a histone demethylase enzyme that has the ability to reverse the trimethyl H3K4 modification state and is revealed to play an important role in the proliferation capacity of breast cancer cells through repression of tumor suppressor genes, including BRCA1.