J
Juan C. Mayo
Researcher at University of Oviedo
Publications - 102
Citations - 12898
Juan C. Mayo is an academic researcher from University of Oviedo. The author has contributed to research in topics: Melatonin & Prostate cancer. The author has an hindex of 47, co-authored 99 publications receiving 11561 citations. Previous affiliations of Juan C. Mayo include University of Texas at San Antonio & International Sleep Products Association.
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Journal ArticleDOI
Regulation of antioxidant enzymes: a significant role for melatonin.
Carmen Rodríguez,Juan C. Mayo,Rosa M. Sainz,Isaac Antolín,Federico Herrera,Vanesa Martín,Russel J. Reiter +6 more
TL;DR: This report reviews the studies which document the influence of melatonin on the activity and expression of the antioxidative enzymes glutathione peroxidase, superoxide dismutases and catalase both under physiological and under conditions of elevated oxidative stress and analyses the possible mechanisms by which melatonin regulates these enzymes.
Journal ArticleDOI
Melatonin as an antioxidant: under promises but over delivers.
Russel J. Reiter,Juan C. Mayo,Dun Xian Tan,Rosa M. Sainz,Moisés Alejandro Alatorre-Jiménez,Lilian Qin +5 more
TL;DR: It is the current feeling of the authors that, in view of the widely diverse beneficial functions that have been reported for melatonin, these may be merely epiphenomena of the more fundamental, yet‐to‐be identified basic action(s) of this ancient molecule.
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Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger.
Dun Xian Tan,Russel J. Reiter,Lucien C. Manchester,Mei ting Yan,Mamdouh R. El-Sawi,Rosa M. Sainz,Juan C. Mayo,Ron Kohen,Mario Allegra,Rudiger Hardeland +9 more
TL;DR: Under in vivo conditions, melatonin is often several times more potent than vitamin C and E in protecting tissues from oxidative injury when compared at an equivalent dosage (micromol/kg).
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Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans.
TL;DR: Melatonin's functions as an antioxidant include: a), direct free radical scavenging, b), stimulation of antioxidative enzymes, c), increasing the efficiency of mitochondrial oxidative phosphorylation and reducing electron leakage (thereby lowering free radical generation), and 3), augmenting the efficiencyof other antioxidants.
Journal ArticleDOI
Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin
Dun Xian Tan,Lucien C. Manchester,Rüdiger Hardeland,Silvia Lopez-Burillo,Juan C. Mayo,Rosa M. Sainz,Russel J. Reiter +6 more
TL;DR: It seems likely that melatonin initially evolved as an antioxidant, becoming a vitamin in the food chain, and in multicellular organisms, where it is produced, it has acquired autocoid, paracoid and hormonal properties.