Showing papers by "Juan J. Fiol published in 2005"
TL;DR: Two new chloride-dimethylsulfoxide-ruthenium(III) complexes, [RuIIICl4(DMSO)(H-Hypoxanthine)] (1) and as discussed by the authors, have been prepared and structurally characterized by X-ray diffraction crystallography.
30 citations
Journal Article•
TL;DR: The effect of zinc, nickel, cobalt and cadmium complexes of acyclovir and its omicron-acetylated derivative (Ac-ACV) on the replication of wild type and ACV-resistant strains of Herpes simplex virus 2 (HSV-2) was examined.
Abstract: The effect of zinc, nickel, cobalt and cadmium complexes of acyclovir (ACV) and its omicron-acetylated derivative (Ac-ACV) on the replication of wild type (wt) and ACV-resistant (ACV(R)) strains of Herpes simplex virus 1 (HSV-1) and Herpes simplex virus 2 (HSV-2) was examined. According to cytotoxicity, these compounds followed the order Ni-ACV chloride > Cd-ACV 3 Ni-ACV nitrate > ACV = Zn-ACV nitrate = Ac-ACV = Zn-Ac-ACV > Zn-ACV chloride > Co-ACV. Besides Ac-ACV, the only active complexes in inhibiting virus replication were Zn-ACV nitrate and Zn-Ac-ACV, which effectively suppressed the growth of both wt and ACVR strains of HSV-1 and HSV-2. The most active and most selective inhibitor of the growth of ACVR strains of HSV-1 and HSV-2 was Ac-ACV; its EC50 and SI were 100 and 10 times higher than those of ACV, respectively. Zn-Ac-ACV was less active than Ac-ACV, obviously due to the stability of the complex. Zn-ACV nitrate was active against both wt and ACVR strains of HSV-1; its activity and selectivity were 100 and 75 times higher than those of ACV, respectively. Ac-ACV and Zn-Ac-ACV suppressed the pre-mitotic arrest caused by HSV-1 infection during the first 2 hrs of infection and later on restored the cell division.
9 citations
TL;DR: Alkylidene-bis(2-aminopyrimidines) (pyr2Cx, x = 2-5) are useful ligands to interact with Ag(I) yielding discrete metallocycles and the solution study shows that the equilibrium constants for the formation of Ag(pyr 2Cx)+ complexes are higher than the literature values for Ag( I) complexes with single pyrimidine.
Abstract: Alkylidene-bis(2-aminopyrimidines)
(pyr2Cx, x
= 2–5) are useful ligands to interact with Ag(I) yielding discrete metallocycles. Crystal structures of the [(pyr2C2)Ag(NO3)]2 and [(H-pyr2C4)Ag(NO3)2]2 have been isolated where each macrocyclic moiety interacts with their surroundings through weak interactions, yielding 3D discrete structures, On the other hand, the solution study shows that the equilibrium constants for the formation of Ag(pyr2Cx)+ complexes are higher than the literature values for Ag(I) complexes with single pyrimidines, although the differences could be explained by invoking the solid-state structures of the Ag(I)–pyr2Cx complexes.
7 citations