J
Judice L. Y. Koh
Researcher at University of Toronto
Publications - 36
Citations - 4876
Judice L. Y. Koh is an academic researcher from University of Toronto. The author has contributed to research in topics: Synthetic genetic array & Promoter. The author has an hindex of 21, co-authored 35 publications receiving 4514 citations. Previous affiliations of Judice L. Y. Koh include Genome Institute of Singapore & Agency for Science, Technology and Research.
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Journal ArticleDOI
The genetic landscape of a cell.
Michael Costanzo,Anastasia Baryshnikova,Jeremy Bellay,Yungil Kim,Eric D. Spear,Carolyn S. Sevier,Huiming Ding,Judice L. Y. Koh,Kiana Toufighi,Sara Mostafavi,Jeany Prinz,Robert P. St.Onge,Benjamin VanderSluis,Taras Makhnevych,Franco J. Vizeacoumar,Solmaz Alizadeh,Sondra Bahr,Renee L. Brost,Yiqun Chen,Murat Cokol,Raamesh Deshpande,Zhijian Li,Zhen Yuan Lin,Wendy Liang,Michaela Marback,Jadine Paw,Bryan Joseph San Luis,Ermira Shuteriqi,Amy Hin Yan Tong,Nydia Van Dyk,Iain M. Wallace,Joseph Whitney,Matthew T. Weirauch,Guoqing Zhong,Hongwei Zhu,Walid A. Houry,Michael Brudno,Sasan Ragibizadeh,Balázs Papp,Csaba Pál,Frederick P. Roth,Guri Giaever,Corey Nislow,Olga G. Troyanskaya,Howard Bussey,Gary D. Bader,Anne-Claude Gingras,Quaid Morris,Philip M. Kim,Chris A. Kaiser,Chad L. Myers,Brenda J. Andrews,Charles Boone +52 more
TL;DR: A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, and highly correlated profiles delineate specific pathways to define gene function.
Journal ArticleDOI
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale
Anastasia Baryshnikova,Michael Costanzo,Yungil Kim,Huiming Ding,Judice L. Y. Koh,Kiana Toufighi,Ji-Young Youn,Jiongwen Ou,Bryan Joseph San Luis,Sunayan Bandyopadhyay,Matthew A. Hibbs,David C. Hess,Anne-Claude Gingras,Gary D. Bader,Olga G. Troyanskaya,Grant W. Brown,Brenda J. Andrews,Charles Boone,Chad L. Myers +18 more
TL;DR: This work has applied the SGA score to examine the relationship between physical and genetic interaction networks, and found that positive genetic interactions connect across functionally distinct protein complexes revealing a network of genetic suppression among loss-of-function alleles.
Journal ArticleDOI
Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
Richard Marcotte,Kevin R. Brown,Fernando Suarez,Azin Sayad,Konstantina Karamboulas,Paul M. Krzyzanowski,Fabrice Sircoulomb,Mauricio Medrano,Yaroslav Fedyshyn,Judice L. Y. Koh,Dewald van Dyk,Bohdana Fedyshyn,Marianna Luhova,Glauber C. Brito,Franco J. Vizeacoumar,Frederick S. Vizeacoumar,Alessandro Datti,Dahlia Kasimer,Alla Buzina,Patricia Mero,Christine M. Misquitta,Josee Normand,Maliha Haider,Troy Ketela,Jeffrey L. Wrana,Robert Rottapel,Benjamin G. Neel,Jason Moffat +27 more
TL;DR: This study identified essential gene profiles in 72 breast, pancreatic, and ovarian cancer cell lines using a lentiviral shRNA library targeting ~16,000 genes and a newly developed, dynamic scoring approach, to facilitate the systematic identification of drivers, unanticipated synthetic lethal relationships, and functional vulnerabilities of these tumor types.
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A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds.
Cheuk Hei Ho,Leslie Magtanong,Sarah L. Barker,David Gresham,Shinichi Nishimura,Paramasivam Natarajan,Judice L. Y. Koh,Justin Porter,Christopher A. Gray,Raymond J. Andersen,Guri Giaever,Corey Nislow,Brenda J. Andrews,David Botstein,Todd R. Graham,Minoru Yoshida,Charles Boone +16 more
TL;DR: A yeast chemical-genomics approach designed to identify genes that when mutated confer drug resistance, thereby providing insight about the modes of action of compounds is presented, and a new class of sterol-binding compounds is discovered.
Journal ArticleDOI
Yeast Proteome Dynamics from Single Cell Imaging and Automated Analysis
Yolanda T. Chong,Judice L. Y. Koh,Helena Friesen,Supipi Kaluarachchi Duffy,Michael J. Cox,Alan M. Moses,Jason Moffat,Charles Boone,Brenda J. Andrews +8 more
TL;DR: To evaluate protein abundance and localization on a proteome scale, the yeast GFP-fusion collection is exploited in a pipeline combining automated genetics, high-throughput microscopy, and computational feature analysis.