Judit Cserepes

TL;DR: This review provides a general overview of the human ABC transporters, their expression, localization and basic mechanism of action, and provides examples for their role in Absorption-Distribution-Metabolism-Excretion (ADME) and toxicology, and describes several basic assays which can be applied for screening drug interactions with ABCtransporters in the course of drug research and development.

TL;DR: Results indicate that multidrug resistance protein modulation by TKIs may be an important factor in the treatment of cancer patients; moreover, the extrusion of TKis by multidrog transporters may result in tumor cell TKI resistance.

TL;DR: Since dimerization is a requirement for half-transporters, it is suggested that both ABCG1 and ABCG4 function as homodimers and it is found that co-expression of theABCG4-KM mutant selectively abolished the ATPase activity of the ABCG 1 and therefore they most probably also heterodimerize.

TL;DR: Surprisingly, red blood cells express hundreds of membrane proteins, which seem to reflect a general genetic and regulatory background, and may serve as relatively stable and easily accessible personalized membrane biomarkers.

TL;DR: It is demonstrated that elevated expression of human ABCG1 is associated with apoptotic cell death in macrophages and also in other cell types, and the results suggest a causative relationship betweenABCG1 function and apoptoticcell death.