Author
Judith H. Waknine
Bio: Judith H. Waknine is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: Parasitemia & Artemisinin. The author has an hindex of 2, co-authored 2 publications receiving 305 citations.
Papers
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TL;DR: Evidence for each mechanism of action attributed to artemisinin includes interference with parasite transport proteins, disruption of parasite mitochondrial function, modulation of host immune function and inhibition of angiogenesis, and the evidence for each is reviewed.
298 citations
TL;DR: The results show that DHA nasal administration to mice was highly efficient in the treatment of Plasmodium infection in infected rodents and this novel mode of drug administration may be considered as an alternative to conventional treatment.
21 citations
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TL;DR: Various strategies based on the Fenton reaction have been employed to enhance hydroxyl radical generation, including nanomaterials selection, modulation of the reaction environment, and external energy fields stimulation, which are discussed systematically in this Minireview.
Abstract: Tailored to the specific tumour microenvironment, which involves acidity and the overproduction of hydrogen peroxide, advanced nanotechnology has been introduced to generate the hydroxyl radical ( OH) primarily for tumour chemodynamic therapy (CDT) through the Fenton and Fenton-like reactions Numerous studies have investigated the enhancement of CDT efficiency, primarily the increase in the amount of OH generated Notably, various strategies based on the Fenton reaction have been employed to enhance OH generation, including nanomaterials selection, modulation of the reaction environment, and external energy fields stimulation, which are discussed systematically in this Minireview Furthermore, the potential challenges and the methods used to facilitate CDT effectiveness are also presented to support this cutting-edge research area
1,190 citations
TL;DR: The current knowledge about the mode of action of ACTs, their pharmacological properties and the proposed mechanisms of drug resistance are discussed.
Abstract: Plasmodium falciparum resistance to chloroquine and sulphadoxine-pyrimethamine has led to the recent adoption of artemisinin-based combination therapies (ACTs) as the first line of treatment against malaria. ACTs comprise semisynthetic artemisinin derivatives paired with distinct chemical classes of longer acting drugs. These artemisinins are exceptionally potent against the pathogenic asexual blood stages of Plasmodium parasites and also act on the transmissible sexual stages. These combinations increase the rates of clinical and parasitological cures and decrease the selection pressure for the emergence of antimalarial resistance. This Review article discusses our current knowledge about the mode of action of ACTs, their pharmacological properties and the proposed mechanisms of drug resistance.
475 citations
TL;DR: This safe and cheap drug class that saves lives at risk from malaria can also have important potential in oncology, and recent advances in defining the role of artemisinins are discussed.
312 citations
TL;DR: In this article, the crystal structure of a plasma membrane proton pump type ATPase was used for identification of modulators of ATPases as well as uses of such modulators.
Abstract: The present invention relates to a crystal structure of a plasma membrane proton pump type ATPase. The invention further describes method for identification of modulators of ATPases as well as uses of such modulators. Based on the provided three dimensional structure of the ATPase, various method, such as computer implemented methods may be used for identification of modulators, such putative modulators may be further analysed using in vitro and in vivo experiments to confirm there functionality. Several modulator interaction regions are described as target of regulation by ATPase modulators.
298 citations
TL;DR: The antiemetic meclizine pretreatment confers cardioprotection and neuroprotection against ischemia-reperfusion injury in murine models andNutrient-sensitized screening may provide a useful framework for understanding gene function and drug action within the context of energy metabolism.
Abstract: Most cells have the inherent capacity to shift their reliance on glycolysis relative to oxidative metabolism, and studies in model systems have shown that targeting such shifts may be useful in treating or preventing a variety of diseases ranging from cancer to ischemic injury. However, we currently have a limited number of mechanistically distinct classes of drugs that alter the relative activities of these two pathways. We screen for such compounds by scoring the ability of >3,500 small molecules to selectively impair growth and viability of human fibroblasts in media containing either galactose or glucose as the sole sugar source. We identify several clinically used drugs never linked to energy metabolism, including the antiemetic meclizine, which attenuates mitochondrial respiration through a mechanism distinct from that of canonical inhibitors. We further show that meclizine pretreatment confers cardioprotection and neuroprotection against ischemia-reperfusion injury in murine models. Nutrient-sensitized screening may provide a useful framework for understanding gene function and drug action within the context of energy metabolism.
287 citations