J
Judith L. Rapoport
Researcher at National Institutes of Health
Publications - 443
Citations - 61482
Judith L. Rapoport is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Schizophrenia & Psychosis. The author has an hindex of 121, co-authored 441 publications receiving 58315 citations. Previous affiliations of Judith L. Rapoport include University of Maryland, Baltimore.
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Journal ArticleDOI
Dynamic mapping of human cortical development during childhood through early adulthood
Nitin Gogtay,Jay N. Giedd,Leslie Lusk,Kiralee M. Hayashi,Deanna Greenstein,A. Catherine Vaituzis,Tom F. Nugent,David H. Herman,Liv S. Clasen,Arthur W. Toga,Judith L. Rapoport,Paul M. Thompson +11 more
TL;DR: The dynamic anatomical sequence of human cortical gray matter development between the age of 4-21 years using quantitative four-dimensional maps and time-lapse sequences reveals that higher-order association cortices mature only after lower-order somatosensory and visual cortices are developed.
Journal ArticleDOI
Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia
Tom Walsh,Jon McClellan,Shane McCarthy,Anjené M. Addington,Sarah B. Pierce,Greg M. Cooper,Alexander Nord,Mary Kusenda,Mary Kusenda,Dheeraj Malhotra,Abhishek Bhandari,Sunday M. Stray,Caitlin Rippey,Patricia Roccanova,Vlad Makarov,B. Lakshmi,Robert L. Findling,Linmarie Sikich,Linmarie Sikich,Thomas Stromberg,Barry Merriman,Nitin Gogtay,Philip Butler,Kristen L. Eckstrand,Laila Noory,Peter Gochman,Robert Long,Zugen Chen,Sean Davis,Carl Baker,Evan E. Eichler,Paul S. Meltzer,Stanley F. Nelson,Andrew B. Singleton,Ming K. Lee,Judith L. Rapoport,Mary Claire King,Jonathan Sebat +37 more
TL;DR: The results suggest that multiple, individually rare mutations altering genes in neurodevelopmental pathways contribute to schizophrenia, and disrupted genes disproportionately from signaling networks controlling neurodevelopment, including neuregulin and glutamate pathways.
Journal ArticleDOI
Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation
Philip Shaw,Kristen L. Eckstrand,Wendy Sharp,Jonathan D. Blumenthal,Jason P. Lerch,Dede Greenstein,Liv S. Clasen,Alan C. Evans,Jay N. Giedd,Judith L. Rapoport +9 more
TL;DR: Maturation to progress in a similar manner regionally in both children with and without ADHD, with primary sensory areas attaining peak cortical thickness before polymodal, high-order association areas, and there was a marked delay in ADHD in attainingpeak thickness throughout most of the cerebrum.
Journal ArticleDOI
Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder.
F. Xavier Castellanos,F. Xavier Castellanos,Patti P. Lee,Wendy Sharp,Neal Jeffries,Deanna Greenstein,Liv S. Clasen,Jonathan D. Blumenthal,Regina James,Christen L. Ebens,James M. Walter,Alex P. Zijdenbos,Alan C. Evans,Jay N. Giedd,Judith L. Rapoport +14 more
TL;DR: Developmental trajectories for all structures, except caudate, remain roughly parallel for patients and controls during childhood and adolescence, suggesting that genetic and/or early environmental influences on brain development in ADHD are fixed, nonprogressive, and unrelated to stimulant treatment.
Journal ArticleDOI
Neurodevelopmental Trajectories of the Human Cerebral Cortex
Philip Shaw,Noor Jehan Kabani,Jason P. Lerch,Kristen L. Eckstrand,Rhoshel K. Lenroot,Nitin Gogtay,Deanna Greenstein,Liv S. Clasen,Alan C. Evans,Judith L. Rapoport,Jay N. Giedd,Steve P. Wise +11 more
TL;DR: By mapping a key characteristic of these development trajectories (the age of attaining peak cortical thickness), this work documents the dynamic, heterochronous maturation of the cerebral cortex through time lapse sequences (“movies”).