Judy Peshu

TL;DR: Prolonged courses of artemisinin-based combination therapies are currently efficacious in areas where standard 3-day treatments are failing, and the incidence of pretreatment and post-treatment gametocytemia was higher among patients with slow parasite clearance, suggesting greater potential for transmission.

TL;DR: The fraction of febrile children with positive malaria smears per homestead and the mean age of children with malaria per Homestead were inversely correlated, indicating that children in homesteads at higher transmission acquire immunity more rapidly.

TL;DR: The significant, albeit small, decline through time of parasitological response rates to treatment with ACTs may be due to the emergence of parasites with reduced drug sensitivity, to the coincident reduction in population-level clinical immunity, or both.

TL;DR: The recommended dose of artemether-lumefantrine provides reliable efficacy in most patients with uncomplicated malaria, however, therapeutic efficacy was lowest in young children from Asia and young underweight children from Africa; a higher dose regimen should be assessed in these groups.

TL;DR: The effect of food intake on oral lumefantrine bioavailability in African children with malaria is evaluated.