J
Jules A. Hoffmann
Researcher at University of Strasbourg
Publications - 247
Citations - 46308
Jules A. Hoffmann is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Ecdysone & Innate immune system. The author has an hindex of 106, co-authored 244 publications receiving 43596 citations. Previous affiliations of Jules A. Hoffmann include Exelixis & Rhône-Poulenc.
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Journal ArticleDOI
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
TL;DR: It is shown that mutations in the Toll signaling pathway dramatically reduce survival after fungal infection and the intracellular components of the dorsoventral signaling pathway and the extracellular Toll ligand, spätzle, control expression of the antifungal peptide gene drosomycin in adults.
Journal ArticleDOI
The Host Defense of Drosophila melanogaster
Bruno Lemaitre,Jules A. Hoffmann +1 more
TL;DR: The current knowledge of the molecular mechanisms underlying Drosophila defense reactions together with strategies evolved by pathogens to evade them are reviewed.
Journal ArticleDOI
Phylogenetic Perspectives in Innate Immunity
TL;DR: In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.
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The role of neuropeptide Y in the antiobesity action of the obese gene product.
Thomas W. Stephens,Margret Barbara Basinski,P K Bristow,Julie M Bue-Valleskey,S G Burgett,L Craft,John E. Hale,Jules A. Hoffmann,Hansen M. Hsiung,Aidas Kriauciunas +9 more
TL;DR: In this paper, a truncated inactive protein was found to suppress food intake and decrease body weight in normal and ob/ob mice but not db/db (diabetic) mice, which are thought to lack the appropriate receptor.
Journal ArticleDOI
The immune response of Drosophila.
TL;DR: Analysis of this defence by molecular genetics has now provided a global picture of the mechanisms by which this insect senses infection, discriminates between various classes of microorganisms and induces the production of effector molecules, among which antimicrobial peptides are prominent.