J
Julia M. Marchingo
Researcher at University of Dundee
Publications - 26
Citations - 865
Julia M. Marchingo is an academic researcher from University of Dundee. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 9, co-authored 22 publications receiving 546 citations. Previous affiliations of Julia M. Marchingo include University of Melbourne & Walter and Eliza Hall Institute of Medical Research.
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Journal ArticleDOI
Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion
Julia M. Marchingo,Julia M. Marchingo,Andrey Kan,Andrey Kan,Robyn M. Sutherland,Robyn M. Sutherland,Ken R. Duffy,Cameron J. Wellard,Cameron J. Wellard,Gabrielle T. Belz,Gabrielle T. Belz,Andrew M. Lew,Andrew M. Lew,Mark R. Dowling,Mark R. Dowling,Mark R. Dowling,Susanne Heinzel,Susanne Heinzel,Philip D. Hodgkin,Philip D. Hodgkin +19 more
TL;DR: In this article, the authors report that T cell receptor (TCR) and costimulatory signals imprint an early, cell-intrinsic, division fate, whereby cells effectively count through generations before returning automatically to a quiescent state.
Journal ArticleDOI
A Myc-dependent division timer complements a cell-death timer to regulate T cell and B cell responses
Susanne Heinzel,Susanne Heinzel,Tran Binh Giang,Tran Binh Giang,Andrey Kan,Andrey Kan,Julia M. Marchingo,Julia M. Marchingo,Julia M. Marchingo,Bryan K Lye,Bryan K Lye,Lynn M. Corcoran,Lynn M. Corcoran,Philip D. Hodgkin,Philip D. Hodgkin +14 more
TL;DR: T lymphocytes and B lymphocytes integrate activating signals to control the size of their proliferative response, and control was achieved by timed changes in the production rate of cell-cycle-regulating proto-oncoprotein Myc, with division cessation occurring when Myc levels fell below a critical threshold.
Journal ArticleDOI
Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation
TL;DR: This study provides a comprehensive map of how Myc selectively shapes T cell phenotypes, revealing that Myc induction of amino acid transport is pivotal for subsequent bioenergetic and biosynthetic programs and licences T cell receptor driven proteome reprogramming.
Journal ArticleDOI
Stretched cell cycle model for proliferating lymphocytes
Mark R. Dowling,Andrey Kan,Andrey Kan,Susanne Heinzel,Susanne Heinzel,Jie H. S. Zhou,Jie H. S. Zhou,Julia M. Marchingo,Julia M. Marchingo,Cameron J. Wellard,Cameron J. Wellard,John F. Markham,John F. Markham,Philip D. Hodgkin,Philip D. Hodgkin +14 more
TL;DR: A stretched cell cycle model is proposed, a novel and improved mathematical description of cell cycle progression for proliferating lymphocytes that can be used to deduce cell cycle parameters for lymphocytes from DNA and BrdU labeling and will be useful when comparing the effects of different stimuli, or therapeutic treatments on immune responses.
Journal ArticleDOI
The regulation of lymphocyte activation and proliferation.
TL;DR: Both robust clonal expansion of a small number of antigen specific T cells, and the concurrent emergence of extensive cellular diversity, confers immunity to a vast array of different pathogens.