J
Julian A. Codelli
Researcher at California Institute of Technology
Publications - 12
Citations - 5003
Julian A. Codelli is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Enantioselective synthesis & Cycloaddition. The author has an hindex of 9, co-authored 12 publications receiving 4349 citations. Previous affiliations of Julian A. Codelli include University of California, Berkeley & University of California, Davis.
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Journal ArticleDOI
Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders
Elaine Y. Hsiao,Sara Mcbride,Sophia Hsien,Gil Sharon,Embriette R. Hyde,Tyler McCue,Julian A. Codelli,Janet Chow,Sarah E. Reisman,Joseph F. Petrosino,Paul H. Patterson,Sarkis K. Mazmanian +11 more
TL;DR: A gut-microbiome-brain connection in a mouse model of ASD is supported and a potential probiotic therapy for GI and particular behavioral symptoms in human neurodevelopmental disorders is identified.
Journal ArticleDOI
Copper-free click chemistry for dynamic in vivo imaging
Jeremy M. Baskin,Jennifer A. Prescher,Scott T. Laughlin,Nicholas J. Agard,Pamela V. Chang,Isaac A. Miller,Anderson Lo,Julian A. Codelli,Carolyn R. Bertozzi +8 more
TL;DR: A Cu-free variant of click chemistry that can label biomolecules rapidly and selectively in living systems, overcoming the intrinsic toxicity of the canonical Cu-catalyzed reaction is reported.
Journal ArticleDOI
Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry
TL;DR: A novel class of DIFO reagents for copper-free click chemistry that are considerably more synthetically tractable are reported and should expand the use of copper- free click chemistry in the hands of biologists.
Journal ArticleDOI
Fluorophore Targeting to Cellular Proteins via Enzyme-Mediated Azide Ligation and Strain-Promoted Cycloaddition
Jennifer Z. Yao,Chayasith Uttamapinant,Andrei Poloukhtine,Jeremy M. Baskin,Julian A. Codelli,Ellen M. Sletten,Carolyn R. Bertozzi,Vladimir V. Popik,Alice Y. Ting +8 more
TL;DR: This work found that fluorophore conjugates to aza-dibenzocyclooctyne (ADIBO) gave the highest and most specific derivatization of azide-conjugated LAP in cells, and optimized two-step enzymatic/chemical labeling scheme was used to tag and image a variety of LAP fusion proteins in multiple mammalian cell lines with diverse fluorophores.
Journal ArticleDOI
Enantioselective total synthesis of (-)-acetylaranotin, a dihydrooxepine epidithiodiketopiperazine.
TL;DR: The first total synthesis of the dihydrooxepine-containing epidithiodiketopiperazine (ETP) (-)-acetylaranotin (1) is reported and it is anticipated that the approach described herein will serve as a general strategy for the synthesis of additional members of thedihydro oxepine ETP family.