Julian J. Lum

TL;DR: This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a stereotyped platform supporting proliferation of diverse cell types and regulates regulation of these fluxes by cellular mediators of signal transduction and gene expression.

TL;DR: Using growth factor-dependent cells from Bax/Bak-deficient mice, it is demonstrated that apoptosis is not essential to limit cell autonomous survival and growth factor signal transduction is required to direct the utilization of sufficient exogenous nutrients to maintain cell viability.

TL;DR: Metformin is selectively toxic to p53-deficient cells and provides a potential mechanism for the reduced incidence of tumors observed in patients being treated with metformin.

TL;DR: Despite evolving the ability to maintain a constant supply of extracellular nutrients, metazoans have retained a complete set of autophagy genes, and the physiological relevance ofautophagy in such species is just beginning to be explored.

TL;DR: It is suggested that HIF-1alpha contributes to the regulation of growth factor-stimulated glucose metabolism even in the absence of hypoxia.