Julie E. Horowitz

TL;DR: Monogenic IBD is rare but should be considered in analysis of all patients with pediatric onset of IBD, and 1% of the patients had variants that could be potentially corrected with allogeneic hematopoietic stem cell transplantation.

TL;DR: In this article, the authors used exome sequence data to investigate associations between rare genetic variants and seven COVID-19 outcomes in 586,157 individuals, including 20,952 with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a respiratory illness causing hospitalization or death.

TL;DR: Itepekimab, a monoclonal antibody targeting IL-33, demonstrated clinical activity in asthma, with potential in chronic obstructive pulmonary disease (COPD).

TL;DR: Seven common genetic variants that modulate COVID-19 susceptibility and severity are identified, implicating IFNAR2, CCHCR1, TCF19, SLC6A20 and the hyaluronan pathway as potential therapeutic targets.

TL;DR: The authors' analyses corroborate the association with the 3p21.31 locus and highlight that there are no rare protein-coding variant associations with effect sizes detectable at current sample sizes, as well as identifying two loci associated with risk of infection at P<5x10-8.