J
Julie Messiaen
Researcher at Katholieke Universiteit Leuven
Publications - 12
Citations - 224
Julie Messiaen is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 3 publications receiving 36 citations.
Papers
More filters
Journal ArticleDOI
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization.
Ana Rita Pombo Antunes,Isabelle Scheyltjens,Francesca Lodi,Julie Messiaen,Asier Antoranz,Johnny Duerinck,Daliya Kancheva,Liesbet Martens,Karen De Vlaminck,Hannah Van Hove,Signe Schmidt Kjølner Hansen,Francesca Maria Bosisio,Koen Van der Borght,Steven De Vleeschouwer,Steven De Vleeschouwer,Raf Sciot,Luc Bouwens,M. Verfaillie,Niels Vandamme,Roosmarijn E. Vandenbroucke,Olivier De Wever,Yvan Saeys,Martin Guilliams,Conny Gysemans,Bart Neyns,Frederik De Smet,Diether Lambrechts,Jo A. Van Ginderachter,Kiavash Movahedi +28 more
TL;DR: This article employed single-cell RNA sequencing and CITE-seq to map the glioblastoma immune landscape in mouse tumors and in patients with newly diagnosed disease or recurrence.
Journal ArticleDOI
Next-Generation Pathology Using Multiplexed Immunohistochemistry: Mapping Tissue Architecture at Single-Cell Level
L. Bosisio,Yannick Van Herck,Julie Messiaen,Maddalena Maria Bolognesi,L. Marcelis,Matthias Van Haele,Giorgio Cattoretti,Asier Antoranz,Frederik De Smet +8 more
TL;DR: This review provides a comprehensive overview of the available technologies for multiplexed immunohistochemistry, their advantages and challenges, and provides the principles on how to interpret high-dimensional data in a spatial context.
Posted ContentDOI
Immunogenomic, single-cell and spatial dissection of CD8+T cell exhaustion reveals critical determinants of cancer immunotherapy
S. Naulaerts,Daniel M Borras,Asier Antoranz Martinez,Julie Messiaen,Y. Van Herck,Lendert Gelens,T. Venken,Isaure Vanmeerbeek,S. More,Jenny Sprooten,Oliver Bechter,Gabriele Bergers,Adrian Liston,S. De Vleeschouwer,B Van den Eynde,D Lambrechts,Jannie Borst,Francesca Maria Bosisio,Sabine Tejpar,F. De Smet,Abhishek D. Garg +20 more
TL;DR: In this paper, a large-scale multi-omics and multi-dimensional mapping of CD8+T cell-state across multiple cancer patient-cohorts was conducted to identify tumour-specific continuum of cell-states across 6 human cancers, partly imprinted by organ-specific immuno-modulatory niches.
Journal ArticleDOI
Multiomics and spatial mapping characterizes human CD8+ T cell states in cancer
Stefan Naulaerts,Angeliki Datsi,Daniel M. Borràs,Asier Antoranz Martinez,Julie Messiaen,Isaure Vanmeerbeek,Jenny Sprooten,Raquel S. Laureano,Jannes Govaerts,Dena Panovska,Marleen Derweduwe,Michael Sabel,Marion Rapp,Weiming Ni,Sean Mackay,Yannick Van Herck,Lendert Gelens,Tom Venken,Sanket More,Oliver Bechter,Gabriele Bergers,Adrian Liston,Steven De Vleeschouwer,Benoît Van den Eynde,Diether Lambrechts,M. Verfaillie,L. Bosisio,Sabine Tejpar,Jannie Borst,Rüdiger V. Sorg,Frederik De Smet,Abhishek D. Garg +31 more
TL;DR: Naulaerts et al. as mentioned in this paper used multi-omics analysis of CD8+ T cell features across multiple patient cohorts and tumor types to identify tumor niche-dependent exhausted and other types of hypofunctional T cell states.
Journal ArticleDOI
Generation of patient-derived models from a metastatic pediatric diffuse leptomeningeal glioneuronal tumor with KIAA1549::BRAF fusion
Julie Messiaen,Annelies Claeys,Aniket Shetty,Lien Spans,Marleen Derweduwe,Anne Uyttebroeck,Bart Depreitere,Isabelle Vanden Bempt,Raf Sciot,Keith L. Ligon,David T. Jones,Sandra Jacobs,Frederik De Smet +12 more
TL;DR: The extraneural spreading of a DLGNT in a child to the abdominal cavity and the iliac and femoral bones is discussed in a 7-year-old girl previously treated with a ventriculoperitoneal shunt for a Dandy–Walker malformation.