J
Julie St-Pierre
Researcher at University of Ottawa
Publications - 81
Citations - 9398
Julie St-Pierre is an academic researcher from University of Ottawa. The author has contributed to research in topics: Mitochondrion & Cancer. The author has an hindex of 36, co-authored 70 publications receiving 7575 citations. Previous affiliations of Julie St-Pierre include McGill University.
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Journal ArticleDOI
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
TL;DR: The data indicate that AMPK phosphorylation of PGC-1α initiates many of the important gene regulatory functions of AMPK in skeletal muscle.
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mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation
Masahiro Morita,Simon-Pierre Gravel,Valérie Chénard,Kristina Sikström,Liang Zheng,Tommy Alain,Valentina Gandin,Daina Avizonis,Meztli Arguello,Chadi Zakaria,Shannon McLaughlan,Yann Nouët,Arnim Pause,Michael Pollak,Eyal Gottlieb,Ola Larsson,Julie St-Pierre,Ivan Topisirovic,Nahum Sonenberg +18 more
TL;DR: It is demonstrated that mTORC1 controls mitochondrial activity and biogenesis by selectively promoting translation of nucleus-encoded mitochondria-related mRNAs via inhibition of the eukaryotic translation initiation factor 4E (eIF4E)-binding proteins (4E-BPs).
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PGC1α and mitochondrial metabolism--emerging concepts and relevance in ageing and neurodegenerative disorders.
Shane Austin,Julie St-Pierre +1 more
TL;DR: How the biogenesis and remodelling of mitochondria that are elicited by PGC1&agr; contribute to an increase in oxidative metabolism and the preservation of ROS homeostasis is discussed and the importance in ageing and neurodegenerative disorders is examined.
Journal ArticleDOI
A roadmap for interpreting 13 C metabolite labeling patterns from cells
Joerg Martin Buescher,Maciek R. Antoniewicz,Laszlo G. Boros,Shawn C. Burgess,Henri Brunengraber,Clary B. Clish,Ralph J. DeBerardinis,Olivier Feron,Christian Frezza,Bart Ghesquière,Eyal Gottlieb,Karsten Hiller,Russell G. Jones,Jurre J. Kamphorst,Richard G. Kibbey,Alec C. Kimmelman,Jason W. Locasale,Sophia Y. Lunt,Oliver D. K. Maddocks,Craig R. Malloy,Christian M. Metallo,Emmanuelle J. Meuillet,Joshua Munger,Katharina Nöh,Joshua D. Rabinowitz,Markus Ralser,Markus Ralser,Uwe Sauer,Gregory Stephanopoulos,Julie St-Pierre,Daniel A. Tennant,Christoph Wittmann,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Alexei Vazquez,Karen H. Vousden,Jamey D. Young,Nicola Zamboni,Sarah-Maria Fendt +38 more
TL;DR: Key issues in interpreting (13)C metabolite labeling patterns are reviewed, with the goal of drawing accurate conclusions from steady state and dynamic stable isotopic tracer experiments.
Journal ArticleDOI
PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer
Fanny Dupuy,Sébastien Tabariès,Sylvia Andrzejewski,Zhifeng Dong,Julianna Blagih,Matthew G. Annis,Atilla Omeroglu,Dongxia Gao,Samuel Leung,Eitan Amir,Mark Clemons,Adriana Aguilar-Mahecha,Mark Basik,Emma E. Vincent,Julie St-Pierre,Russell G. Jones,Peter M. Siegel +16 more
TL;DR: It is demonstrated that PDK1 is required for efficient liver metastasis, and its expression is elevated in liver metastases from breast cancer patients, and the data implicatePDK1 as a key regulator of metabolism and metastatic potential in breast cancer.