J
Julien Duc
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 27
Citations - 1907
Julien Duc is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Zinc finger & Gene. The author has an hindex of 13, co-authored 19 publications receiving 1312 citations.
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Journal ArticleDOI
Molecular Criteria for Defining the Naive Human Pluripotent State
Thorold W. Theunissen,Marc Friedli,Yupeng He,Yupeng He,Evarist Planet,Ryan C. O’Neil,Ryan C. O’Neil,Styliani Markoulaki,Julien Pontis,Haoyi Wang,Alexandra Iouranova,Michael Imbeault,Julien Duc,Malkiel A. Cohen,Katherine J. Wert,Rosa Castanon,Zhuzhu Zhang,Yanmei Huang,Joseph R. Nery,Jesse Drotar,Tenzin Lungjangwa,Didier Trono,Joseph R. Ecker,Rudolf Jaenisch +23 more
TL;DR: It is shown that transcription of transposable elements provides a sensitive measure of the concordance between pluripotent stem cells and early human development and induction of the naive state is accompanied by genome-wide DNA hypomethylation.
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DUX-family transcription factors regulate zygotic genome activation in placental mammals
TL;DR: Evidence is provided that the DUX family of transcription factors is essential to the activation of zygotic genome activation in placental mammals in mice and potentially in humans.
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Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs
Julien Pontis,Evarist Planet,Sandra Offner,Priscilla Turelli,Julien Duc,Alexandre Coudray,Thorold W. Theunissen,Rudolf Jaenisch,Didier Trono +8 more
TL;DR: By controlling the transcriptional impact of TEs during embryogenesis, KZFPs facilitate their genome-wide incorporation into transcriptional networks, thereby contributing to human genome regulation.
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Evolutionally dynamic L1 regulation in embryonic stem cells
Nathaly Castro-Diaz,Gabriela Ecco,Andrea Coluccio,Adamandia Kapopoulou,Benyamin Yazdanpanah,Marc Friedli,Julien Duc,Suk Min Jang,Priscilla Turelli,Didier Trono +9 more
TL;DR: In human embryonic stem (hES) cells, KAP1 (KRAB-containing zinc finger proteins) represses a discrete subset of L1 lineages predicted to have entered the ancestral genome between 26.8 million and 7.6 million years ago, supporting a model in which newly emerged lineages are first suppressed by DNA methylation-inducing small RNA-based mechanisms before K AP1-recruiting protein repressors are selected.
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Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues.
Gabriela Ecco,Marco Cassano,Annamaria Kauzlaric,Julien Duc,Andrea Coluccio,Sandra Offner,Michael Imbeault,Helen M. Rowe,Priscilla Turelli,Didier Trono +9 more
TL;DR: It is uncovered that these KRAB-ZFPs and KAP1 control TEs in adult tissues, in cell culture and in vivo, where they partner up to modulate cellular genes, which likely regulate not only development but also many physiological events.