J
Julien F. Ayroles
Researcher at Princeton University
Publications - 73
Citations - 5875
Julien F. Ayroles is an academic researcher from Princeton University. The author has contributed to research in topics: Population & Gene. The author has an hindex of 23, co-authored 58 publications receiving 5124 citations. Previous affiliations of Julien F. Ayroles include University of Illinois at Urbana–Champaign & Cornell University.
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Journal ArticleDOI
The Drosophila melanogaster Genetic Reference Panel
Trudy F. C. Mackay,Stephen Richards,Eric A. Stone,Antonio Barbadilla,Julien F. Ayroles,Julien F. Ayroles,Dianhui Zhu,Sònia Casillas,Yi Han,Michael M. Magwire,Julie M. Cridland,Mark F. Richardson,Robert R. H. Anholt,Maite G. Barrón,Crystal Bess,Kerstin P. Blankenburg,Mary Anna Carbone,David Castellano,Lesley S. Chaboub,Laura H Duncan,Zeke Harris,Mehwish Javaid,Joy Jayaseelan,Shalini N. Jhangiani,Katherine W. Jordan,Fremiet Lara,Faye Lawrence,Sandra L. Lee,Pablo Librado,Raquel S. Linheiro,Richard F. Lyman,Aaron J. Mackey,Mala Munidasa,Donna M. Muzny,Lynne V. Nazareth,Irene Newsham,Lora Perales,Ling-Ling Pu,Carson Qu,Miquel Ràmia,Jeffrey G. Reid,Stephanie M. Rollmann,Stephanie M. Rollmann,Julio Rozas,Nehad Saada,Lavanya Turlapati,Kim C. Worley,Yuanqing Wu,Akihiko Yamamoto,Yiming Zhu,Casey M. Bergman,Kevin R. Thornton,David Mittelman,Richard A. Gibbs +53 more
TL;DR: The Drosophila melanogaster Genetic Reference Panel is described, a community resource for analysis of population genomics and quantitative traits, which reveals reduced polymorphism in centromeric autosomal regions and the X chromosomes, evidence for positive and negative selection, and rapid evolution of the X chromosome.
Journal ArticleDOI
The genetics of quantitative traits: challenges and prospects.
TL;DR: The principles of quantitative trait locus mapping are reviewed and insights about the genetic architecture of quantitative traits that have been obtained over the past decades are summarized.
Journal ArticleDOI
Systems genetics of complex traits in Drosophila melanogaster.
Julien F. Ayroles,Mary Anna Carbone,Eric A. Stone,Katherine W. Jordan,Richard F. Lyman,Michael M. Magwire,Michael M. Magwire,Stephanie M. Rollmann,Stephanie M. Rollmann,Laura H Duncan,Faye Lawrence,Robert R. H. Anholt,Trudy F. C. Mackay +12 more
TL;DR: The authors quantified genome-wide transcript abundance and phenotypes for six ecologically relevant traits in D. melanogaster wild-derived inbred lines and observed 10,096 genetically variable transcripts and high heritabilities for all organismal phenotypes.
Journal ArticleDOI
Epistasis dominates the genetic architecture of Drosophila quantitative traits.
Wen Huang,Stephen Richards,Mary Anna Carbone,Dianhui Zhu,Robert R. H. Anholt,Julien F. Ayroles,Laura H Duncan,Katherine W. Jordan,Faye Lawrence,Michael M. Magwire,Crystal B. Warner,Kerstin P. Blankenburg,Yi Han,Mehwish Javaid,Joy Jayaseelan,Shalini N. Jhangiani,Donna M. Muzny,Fiona Ongeri,Lora Perales,Yuan Qing Wu,Yiqing Zhang,Xiaoyan Zou,Eric A. Stone,Richard A. Gibbs,Trudy F. C. Mackay +24 more
TL;DR: In this article, the authors compared the genetic architecture of three Drosophila life history traits in the sequenced inbred lines of the melanogaster Genetic Reference Panel (DGRP) and a large outbred, advanced intercross population derived from 40 DGRP lines (Flyland).
Journal ArticleDOI
Using Whole-Genome Sequence Data to Predict Quantitative Trait Phenotypes in Drosophila melanogaster
Ulrike Ober,Julien F. Ayroles,Julien F. Ayroles,Eric A. Stone,Stephen Richards,Dianhui Zhu,Richard A. Gibbs,Christian Stricker,Daniel Gianola,Martin Schlather,Trudy F. C. Mackay,Henner Simianer +11 more
TL;DR: It is hypothesized that predictive power in this population stems from the SNP–based modeling of the subtle relationship structure caused by long-range linkage disequilibrium and not from population structure or SNPs in linkage diseqilibrium with causal variants.