J
Julien J. H. Cotelesage
Researcher at University of Saskatchewan
Publications - 33
Citations - 509
Julien J. H. Cotelesage is an academic researcher from University of Saskatchewan. The author has contributed to research in topics: Absorption spectroscopy & X-ray absorption spectroscopy. The author has an hindex of 12, co-authored 29 publications receiving 405 citations. Previous affiliations of Julien J. H. Cotelesage include Canadian Light Source.
Papers
More filters
Journal ArticleDOI
Metalloprotein active site structure determination: synergy between X-ray absorption spectroscopy and X-ray crystallography.
Julien J. H. Cotelesage,M. Jake Pushie,Pawel Grochulski,Ingrid J. Pickering,Graham N. George +4 more
TL;DR: The potential of X-ray absorption spectroscopy to provide information and perspective which could aid in improving the accuracy of metalloprotein crystal structure solutions is reviewed.
Journal ArticleDOI
Structural basis of enzymatic benzene ring reduction
Tobias Weinert,Simona G. Huwiler,Johannes W. Kung,Sina Weidenweber,Petra Hellwig,Hans-Joachim Stärk,Till Biskup,Stefan Weber,Julien J. H. Cotelesage,Graham N. George,Ulrich Ermler,Matthias Boll +11 more
TL;DR: The structural characterization of a dearomatizing BCR containing an unprecedented tungsten cofactor that transfers electrons to the benzene ring in an aprotic cavity is presented and shed light on the structural basis of an electron transfer process at the negative redox potential limit in biology.
Journal ArticleDOI
Molybdenum and tungsten oxygen transferases – structural and functional diversity within a common active site motif
TL;DR: Together, the molybdenum and tungsten enzymes form a superfamily which is among the most prevalent known, being found in all kingdoms of life.
Journal ArticleDOI
How does an enzyme recognize CO2
Julien J. H. Cotelesage,Jennifer Puttick,Hughes Goldie,Babak Rajabi,Brian A.A. Novakovski,Louis T. J. Delbaere +5 more
TL;DR: Kinetic studies found that the PCK mutant Arg65Gln increased the K(M) for substrates PEP and oxaloacetate but not for CO(2), which can be explained since the Arg 65Gln mutant likely maintains a hydrogen bond to one of the oxygen atoms of carbon dioxide.
Journal ArticleDOI
The solution structure of the copper clioquinol complex.
M. Jake Pushie,Kurt H. Nienaber,Kelly L. Summers,Julien J. H. Cotelesage,Julien J. H. Cotelesage,Olena Ponomarenko,Helen Nichol,Ingrid J. Pickering,Graham N. George +8 more
TL;DR: The promise of clioquinol in new treatments for Alzheimer's disease and in cancer therapy is not likely to be due to any novel chelation chemistry, but rather due to other factors including the high lipophilicity of the free ligand and chelate complexes.