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Júlio César Conceição Filho

Bio: Júlio César Conceição Filho is an academic researcher from Federal University of São Carlos. The author has contributed to research in topics: Cancer & Naringenin. The author has an hindex of 3, co-authored 5 publications receiving 85 citations.

Papers
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Journal ArticleDOI
TL;DR: This review focused on the cancer chemopreventive effects of [6]-gingerol, the major pungent component of ginger, and its impact on different steps of the metastatic process.
Abstract: For many years, ginger or ginger root, the rhizome of the plant Zingiber officinale, has been consumed as a delicacy, medicine, or spice. Several studies have been conducted on the medicinal properties of ginger against various disorders, including cancer. Cancer is the second leading cause of death, and chemoprevention is defined as the use of natural or synthetic substances to prevent cancer initiation or progression. Evidence that ginger-derived compounds have inhibitory effects on various cancer cell types is increasingly being reported in the scientific literature. In this review we focused on the cancer chemopreventive effects of [6]-gingerol, the major pungent component of ginger, and its impact on different steps of the metastatic process.

51 citations

Journal ArticleDOI
05 Sep 2014-PLOS ONE
TL;DR: It is demonstrated that naringenin complexed with Cu(II) and 2,2′-bipyridine (NGENCuB) was more efficient inhibiting colony formation, proliferation and migration of MDA-MB-231 tumor cells, than naringein (NGEN) itself.
Abstract: Cancer is the second leading cause of death worldwide and there is epidemiological evidence that demonstrates this tendency is emerging. Naringenin (NGEN) is a trihydroxyflavanone that shows various biological effects such as antioxidant, anticancer, anti-inflammatory, and antiviral activities. It belongs to flavanone class, which represents flavonoids with a C6-C3-C6 skeleton. Flavonoids do not exhibit sufficient activity to be used for chemotherapy, however they can be chemically modified by complexation with metals such as copper (Cu) (II) for instance, in order to be applied for adjuvant therapy. This study investigated the effects of Cu(II) and 2,2′-bipyridine complexation with naringenin on MDA-MB-231 cells. We demonstrated that naringenin complexed with Cu(II) and 2,2′-bipyridine (NGENCuB) was more efficient inhibiting colony formation, proliferation and migration of MDA-MB-231 tumor cells, than naringenin (NGEN) itself. Furthermore, we verified that NGENCuB was more effective than NGEN inhibiting pro-MMP9 activity by zymography assays. Finally, through flow cytometry, we showed that NGENCuB is more efficient than NGEN inducing apoptosis in MDA-MB-231 cells. These results were confirmed by gene expression analysis in real time PCR. We observed that NGENCuB upregulated the expression of pro-apoptotic gene caspase-9, but did not change the expression of caspase-8 or anti-apoptotic gene Bcl-2. There are only few works investigating the effects of Cu(II) complexation with naringenin on tumor cells. To the best of our knowledge, this is the first work describing the effects of Cu(II) complexation of a flavonoid on MDA-MB-231 breast tumor cells.

31 citations

Journal ArticleDOI
TL;DR: This study demonstrates that cedrelone inhibits proliferation, adhesion, migration and invasion of breast tumor cells from the line MDA-MB-231 and is the first work describing the effects of a limonoid on tumor and non-tumor cell adhesion process.
Abstract: Cancer is the second leading cause of death, preceded only by cardiovascular diseases, and there is epidemiological evidence that demonstrate this tendency is emerging worldwide. Brazil has an extensive vegetal biodiversity with more than 55,000 species listed. Such biodiversity collaborates with the finding of compounds which could be the basis for the design of new anti-tumor drugs, with fewer side effects than the conventional chemotherapy used currently. Cedrelone is a limonoid isolated from Trichilia catigua (Meliaceae) which is a native Brazilian plant. This study demonstrates that cedrelone inhibits proliferation, adhesion, migration and invasion of breast tumor cells from the line MDA-MB-231. The effects of cell migration and invasion on MDA-MB-231 cell may be explained, at least in part, by the ability of cedrelone to inhibit MMP activity. We also demonstrate that cedrelone is able to induce apoptosis in MDA-MB-231 cells. There are only a few works investigating the effect of limonoids in cellular processes closely related to tumor progression such as adhesion, migration and invasion. To the best of our knowledge, this is the first work describing the effects of a limonoid on tumor and non-tumor cell adhesion process.

12 citations

Journal ArticleDOI
TL;DR: In this article, a comparison of concentracoes plasmaticas of cortisol, GH and insulina for leg press (LP) and supino reto (SR) exercises was conducted.
Abstract: INTRODUCAO: Muitos trabalhos tem estudado o comportamento hormonal nos exercicio resistido, entretanto poucos relacionam os hormonios cortisol, GH e insulina. OBJETIVO: Estudar os ajustes das concentracoes plasmaticas dos hormonios cortisol, GH e insulina em exercicios resistidos de mesma intensidade com relacao a massas musculares distintas. METODOS: Dez voluntarios, com 20,3 ± 4,2 anos, 74,1 ± 10,2 kg de peso, 177,2 ± 4,6 cm de estatura e 23,8 ± 3,2 kg/m2 de IMC, realizaram uma sessao de leg press (LP) e supino reto (SR) com quatro series com 10 repeticoes a 70% 1 RM com tres minutos de intervalo. Foram coletadas amostras de sangue para dosagem das concentracoes plasmaticas de cortisol, GH e insulina em repouso (Pre) e em 0' (Rec. 0'), 30' (Rec. 30') e 90' (Rec. 90') de recuperacao. RESULTADOS: As concentracoes plasmaticas de cortisol foram significativamente reduzidas ao final da recuperacao em LP (2,20±0,37 ng/dl para 1,33±0,38ng/dl) em relacao a pre-dosagem. As concentracoes de GH e insulina elevaram-se significativamente durante a recuperacao. GH em LP foi significativamente maior em Rec. 0' (2,75±3,29 ng/ml para 9,60±5,32 ng/dl) do que em pre. A insulina elevou-se significativamente em Rec. 30' em LP (14,70±7,92 ulU/ml para 21,66 ± 8,61 ulU/ml) e em SR (6,17 ± 2,99 ulU/ml para 19,70 ± 13,8 ulU/ml) em relacao a pre. As concentracoes plasmaticas de insulina pre em LP foram significativamente superiores a SR (14,70 ulU/ml e 6,17 ± 2,99 ulU/ml). CONCLUSAO: O exercicio resistido promoveu diferentes ajustes nas concentracoes hormonais de cortisol, GH e insulina durante o periodo de recuperacao.

2 citations

01 Jan 2014
TL;DR: In this article, the adjustments of plasma concentrations of the cortisol, GH and insulin hormones in resisted exercises of the same relative intensity with different muscle musses were studied. And the results showed that resisted exercise promoted different adjustments in hormone concentrations of cortisol, growth hormone and insulin during the recovery period.
Abstract: Introduction: Many works have studied the hormonal behavior in resistance exercise, however, few relate the cortisol, GH and insulin hormones. Objective: To study the adjustments of plasma concentrations of the cortisol, GH and insulin hormones in resisted exercises of the same relative intensity with different muscle musses. Meth-ods: Ten volunteers, aged 20.3 ± 4.2 years, weight 74.1 ± 10.2 Kg, 177.2 ± 4.6 cm of stature and 23.8 ± 3.2 Kg/m 2 of BMI, underwent a session of leg press (LP) and bench press (BP) with four sets of 10 repetitions at 70% 1 RM with three minutes apart. We collected blood samples to measure plasma concentrations of cortisol, GH and insulin at rest (Pre) and 0’ (Rec. 0’), 30’ (Rec. 30’) and 90’ (Rec. 90’) of recovery. Results: Plasma concentrations of cortisol decreased significantly at the end of the recovery in LP (2.20 ± 0.37 ng/dl to 1.33 ± 0.38 ng/dl) compared to pre. The GH and insulin concentrations significantly increased during recovery. GH was significantly higher in LP Rec. 0’ (2.75 ± 3.29 ng/ml to 9.60 ± 5.32 ng/dl) than in pre. Insulin was significantly elevated in Rec. 30’ in LP(14.70 ± 7.92 ulU/ml to 21.66 ± 8.61 ulU/ml) and BP (6.17 ± 2.99 ulU/ml to 19.70 ± 13.8 ulU/ml) for pre. The plasma insulin concentrations pre PL were significantly higher in the BP (14.70 ulU/ml and 6.17 ± 2.99 ulU/ml). Conclusion: Resisted exercise promoted different adjustments in hormone concentrations of cortisol, GH and insulin during the recovery period.Keywords: physical exercise, hydrocortisone, growth hormone, insulin.

Cited by
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Journal ArticleDOI
TL;DR: The present treatise reviews all the experimentally validated health benefits of this spice, to make a claim on its nutraceutical application.

166 citations

Journal ArticleDOI
TL;DR: The anti-inflammatory activities of naringenin in various disease context and its potential use, as an immunomodulator, in the treatment of inflammatory related disease are discussed.

147 citations

Journal ArticleDOI
TL;DR: This review provides highlights of Naringenin with respect to its distribution, pharmacokinetic and its use in conditions like oxidative stress, inflammation, cancer, diabetes, cardiovascular diseases and neurological disorders.

138 citations

Journal ArticleDOI
TL;DR: In vitro release of [6]-gingerol loaded proliposome compared with the free [6], was significantly higher and its oral bioavailability increased 5-fold in vivo, and its antitumor effect was enhanced in the liposome formulation.

86 citations

Journal Article
TL;DR: Understanding the molecular mechanisms that regulate cell death programs including apoptosis, and how resistant forms of cancer evade apoptotic events, may provide novel opportunities for cancer drug development.
Abstract: Killing of tumor cells by anticancer therapies commonly used in the treatment of cancer, e.g. chemotherapy, gamma-irradiation, immunotherapy or suicide gene therapy, is predominantly mediated by triggering apoptosis, the cell's intrinsic death program. Accordingly, defects in apoptosis pathways can result in cancer resistance to current treatment approaches. Understanding the molecular mechanisms that regulate cell death programs including apoptosis, and how resistant forms of cancer evade apoptotic events, may provide novel opportunities for cancer drug development.

83 citations