J
Jun Chen
Researcher at University of Alabama at Birmingham
Publications - 16
Citations - 10805
Jun Chen is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Peroxynitrite & Superoxide dismutase. The author has an hindex of 9, co-authored 12 publications receiving 10595 citations.
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Journal ArticleDOI
Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.
TL;DR: It is proposed that superoxide dismutase may protect vascular tissue stimulated to produce superoxide and NO under pathological conditions by preventing the formation of peroxynitrite.
Journal ArticleDOI
Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase
Harry Ischiropoulos,Ling Zhu,Jun Chen,Michael Y. Tsai,James C. Martin,Craig D. Smith,Joseph S. Beckman +6 more
TL;DR: The mechanism appears to involve peroxynitrite initially reacting with the active site copper to form an intermediate with the reactivity of nitronium ion (NO2+), which then nitrates tyrosine on a second molecule of superoxide dismutase.
Book ChapterDOI
Oxidative chemistry of peroxynitrite.
TL;DR: This chapter presents that essentially all of the nitric oxide produced by rat alveolar macrophages activated with phorbol ester is converted to peroxynitrite, a strong oxidant that can be stored for weeks in alkaline solution or even entrapped in solid forms.
Journal ArticleDOI
Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite.
Joseph S. Beckman,Harry Ischiropoulos,Ling Zhu,Mark van der Woerd,Craig R. Smith,Jun Chen,Joseph G. Harrison,James C. Martin,Michael Y. Tsai +8 more
TL;DR: It is proposed that peroxynitrite anion is more stable in the cis conformation, whereas only a higher energy species in the trans conformation can fit in the active site of Cu,Zn superoxide dismutase.
Journal ArticleDOI
On the pH-dependent yield of hydroxyl radical products from peroxynitrite
John P. Crow,Christiana Spruell,Jun Chen,Christopher Gunn,Harry Ischiropoulos,Michael Y. Tsai,Craig D. Smith,Rafael Radi,Willem H. Koppenol,Joseph S. Beckman +9 more
TL;DR: It is proposed that the complex oxidative chemistry of peroxynitrite is controlled by the pH-dependent isomerization of the relatively stable cis-configuration to the trans- configuration, which undergoes internal rearrangement to nitrate without forming a strong oxidant.