Jun Zhang

TL;DR: It is shown that alterations in cancer cell mitochondrial oxidative metabolism resulting in increased levels of O2⋅- and H2O2 are capable of disrupting intracellular iron metabolism, thereby selectively sensitizing non-small-cell lung cancer and glioblastoma cells to ascorbate through pro-oxidant chemistry involving redox-active labile iron and H 2O2.

TL;DR: This work demonstrated that low-dose apatinib alleviated hypoxia, increased infiltration of CD8+ T cells, reduced recruitment of tumor-associated macrophages in tumor and decreased TGFβ amounts in both tumor and serum, which shows the rationale for the treatment of lung cancer with a combination of PD-1/PD-L1 blockade and low- dose apatinIB.

TL;DR: This research has demonstrated the successful application of MSNs as a novel nanotechnology in dental materials to inhibit oral biofilm without sacrificing materials’ mechanical properties and surface integrity.

TL;DR: Pyrotinib showed activity against NSCLC with HER2 exon 20 mutations in both patient-derived organoids and a PDX model and showed promising efficacy in the clinical trial.

TL;DR: In this article, a dual-axis scanning microelectromechanical system (MEMS) mirror was used for 3D endoscopic optical coherence tomography (OCT).