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Junbo Gong

Bio: Junbo Gong is an academic researcher from Tianjin University. The author has contributed to research in topics: Solubility & Crystallization. The author has an hindex of 31, co-authored 319 publications receiving 4330 citations. Previous affiliations of Junbo Gong include Qinghai University for Nationalities & Qilu University of Technology.


Papers
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Journal ArticleDOI
TL;DR: The specific targeting and high efficiency of this delivery platform offers a novel approach to limit the toxicity of anticancer agents as well as increasing their efficacy in cancer therapy.
Abstract: Specific targeting and cellular internalization are key properties for carriers of antitumor therapeutic agents. Here, we develop a drug carrier through the attachment of substrate of endoprotease legumain, alanine-alanine-asparagine (AAN), to cell-penetrating peptides (TAT, trans-activating factor). The addition of the AAN moiety to the fourth lysine in the TAT creates a branched peptide moiety, which leads to a decrease in the transmembrane transport capacity of TAT by 72.65%. Legumain efficiently catalyses the release of TAT-liposome from the AAN-TAT-liposome and thereby recovers the penetrating capacity of TAT. Doxorubicin carried by the AAN-TAT-liposome led to an increase in the tumoricidal effect of doxorubicin and a reduction in its systemic adverse effects in comparison with doxorubicin carried by a control delivery system. Thus, the specific targeting and high efficiency of this delivery platform offers a novel approach to limit the toxicity of anticancer agents as well as increasing their efficacy in cancer therapy.

156 citations

Journal ArticleDOI
Dejiang Zhang1, Shijie Xu1, Shichao Du1, Jingkang Wang1, Junbo Gong1 
TL;DR: In this article, the advantages and disadvantages of different types of continuous crystallization are compared, with the main difference between the two main types of crystallizers being their difference in residence time distribution.

140 citations

Journal ArticleDOI
TL;DR: A review of recent developments in crystal engineering and crystallization process design and control in the pharmaceutical industry can be found in this article, where the authors systematically summarize recent methods for understanding and developing new types of crystals such as co-crystals, polymorphs, and solvates, and include several milestones such as the launch of the first cocrystal drug Entresto (Novartis), and the continuous manufacture of Orkambi (Vertex).

134 citations

Journal ArticleDOI
Bo Yu1, Feifei Wang1, Weibing Dong1, Jie Hou1, Lu Pingchao1, Junbo Gong1 
TL;DR: In this article, a self-template method was used to synthesize a core-shell ZnO@zeolitic imidazolate frameworks-8 (ZnO/ZIF-8) nanospheres.

115 citations

Journal ArticleDOI
TL;DR: Comparison of Oct4 expression in MCF-7 and MDA-MB-231 cells shows that silencing Oct4 promotes invasion and metastasis in breast cancer cells by inducing EMT, which may be related to SOCs-directed enhancement of Ca(2+) influx.

106 citations


Cited by
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Journal Article
TL;DR: This book by a teacher of statistics (as well as a consultant for "experimenters") is a comprehensive study of the philosophical background for the statistical design of experiment.
Abstract: THE DESIGN AND ANALYSIS OF EXPERIMENTS. By Oscar Kempthorne. New York, John Wiley and Sons, Inc., 1952. 631 pp. $8.50. This book by a teacher of statistics (as well as a consultant for \"experimenters\") is a comprehensive study of the philosophical background for the statistical design of experiment. It is necessary to have some facility with algebraic notation and manipulation to be able to use the volume intelligently. The problems are presented from the theoretical point of view, without such practical examples as would be helpful for those not acquainted with mathematics. The mathematical justification for the techniques is given. As a somewhat advanced treatment of the design and analysis of experiments, this volume will be interesting and helpful for many who approach statistics theoretically as well as practically. With emphasis on the \"why,\" and with description given broadly, the author relates the subject matter to the general theory of statistics and to the general problem of experimental inference. MARGARET J. ROBERTSON

13,333 citations

01 Jan 2016
TL;DR: The principles of fluorescence spectroscopy is universally compatible with any devices to read and is available in the digital library an online access to it is set as public so you can download it instantly.
Abstract: Thank you very much for downloading principles of fluorescence spectroscopy. As you may know, people have look hundreds times for their favorite novels like this principles of fluorescence spectroscopy, but end up in malicious downloads. Rather than reading a good book with a cup of tea in the afternoon, instead they cope with some harmful bugs inside their desktop computer. principles of fluorescence spectroscopy is available in our digital library an online access to it is set as public so you can download it instantly. Our digital library spans in multiple locations, allowing you to get the most less latency time to download any of our books like this one. Kindly say, the principles of fluorescence spectroscopy is universally compatible with any devices to read.

2,960 citations

01 Feb 1995
TL;DR: In this paper, the unpolarized absorption and circular dichroism spectra of the fundamental vibrational transitions of the chiral molecule, 4-methyl-2-oxetanone, are calculated ab initio using DFT, MP2, and SCF methodologies and a 5S4P2D/3S2P (TZ2P) basis set.
Abstract: : The unpolarized absorption and circular dichroism spectra of the fundamental vibrational transitions of the chiral molecule, 4-methyl-2-oxetanone, are calculated ab initio. Harmonic force fields are obtained using Density Functional Theory (DFT), MP2, and SCF methodologies and a 5S4P2D/3S2P (TZ2P) basis set. DFT calculations use the Local Spin Density Approximation (LSDA), BLYP, and Becke3LYP (B3LYP) density functionals. Mid-IR spectra predicted using LSDA, BLYP, and B3LYP force fields are of significantly different quality, the B3LYP force field yielding spectra in clearly superior, and overall excellent, agreement with experiment. The MP2 force field yields spectra in slightly worse agreement with experiment than the B3LYP force field. The SCF force field yields spectra in poor agreement with experiment.The basis set dependence of B3LYP force fields is also explored: the 6-31G* and TZ2P basis sets give very similar results while the 3-21G basis set yields spectra in substantially worse agreements with experiment. jg

1,652 citations

Journal ArticleDOI
TL;DR: This review highlights the advances in the use of MOFs in the elimination (adsorption and/or degradation) of EOCs from water, classifying them by the nature of the contaminant.
Abstract: Water is essential in all aspects of life, being the defining characteristic of our planet and even our body. Regrettably, water pollution is increasingly becoming a challenge due to novel anthropogenic pollutants. Of particular concern are emerging organic contaminants (EOCs), the term used not only to cover newly developed compounds but also compounds newly discovered as contaminants in the environment. Aside from anthropogenic contamination, higher temperature and more extreme and less predictable weather conditions are projected to affect water availability and distribution. Therefore, wastewater treatment has to become a valuable water resource and its reuse is an important issue that must be carried out efficiently. Among the novel technologies considered in water remediation processes, metal-organic frameworks (MOFs) are regarded as promising materials for the elimination of EOCs since they present many properties that commend them in water treatment: large surface area, easy functionalizable cavities, some are stable in water, and synthesized at large scale, etc. This review highlights the advances in the use of MOFs in the elimination (adsorption and/or degradation) of EOCs from water, classifying them by the nature of the contaminant.

542 citations

Book
26 Aug 2009
TL;DR: The literature on solubility data for pharmaceuticals has changed in recent years from being mainly concerned with liquid chromatography to gas chromatography and now also includes “solid-phase” data.
Abstract: Handbook of solubility data for pharmaceuticals , Handbook of solubility data for pharmaceuticals , کتابخانه دیجیتال جندی شاپور اهواز

477 citations