J
Junji Ishida
Researcher at University of Tsukuba
Publications - 74
Citations - 4180
Junji Ishida is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Angiotensin II & Renin–angiotensin system. The author has an hindex of 30, co-authored 71 publications receiving 3811 citations. Previous affiliations of Junji Ishida include Yokohama City University & Chiba University.
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Journal ArticleDOI
Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo
Junji Ishida,Tatsuo Hashimoto,Tatsuo Hashimoto,Yasumi Hashimoto,Shiro Nishiwaki,Taku Iguchi,Shuichi Harada,Takeshi Sugaya,Hitomi Matsuzaki,Rie Yamamoto,Naotaka Shiota,Hideki Okunishi,Minoru Kihara,Satoshi Umemura,Fumihiro Sugiyama,Ken-ichi Yagami,Yoshitoshi Kasuya,Naoki Mochizuki,Akiyoshi Fukamizu +18 more
TL;DR: It is demonstrated that APJ exerts the hypotensive effect in vivo and plays a counterregulatory role against the pressor action of angiotensin II.
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Angiotensinogen-deficient mice with hypotension.
Keiji Tanimoto,Fumihiro Sugiyama,Yu-ichi Goto,Junji Ishida,Eriko Takimoto,Ken-ichi Yagami,Akiyoshi Fukamizu,Kazuo Murakami +7 more
TL;DR: The present study generated angiotensinogen-deficient mice by homologous recombination in mouse embryonic stem cells, resulting in the complete loss of plasma immunoreactive ang Elliotensin I.
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Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1.
Kazuyuki Yamagata,Hiroaki Daitoku,Yoko Shimamoto,Hitomi Matsuzaki,Keiko Hirota,Junji Ishida,Akiyoshi Fukamizu +6 more
TL;DR: It is reported that bile acids inhibit the expression of gluconeogenic genes, including glucose-6-phosphatase (G6Pase), phosphoenolpyruvate carboxykinase, and fructose 1,6-bis phosphatase in an SHP-dependent fashion.
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The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice
Shigetomo Fukuhara,Szandor Simmons,Shunsuke Kawamura,Asuka Inoue,Yasuko Orba,Takeshi Tokudome,Yuji Sunden,Yuji Arai,Kazumasa Moriwaki,Junji Ishida,Akiyoshi Uemura,Hiroshi Kiyonari,Takaya Abe,Akiyoshi Fukamizu,Masanori Hirashima,Hirofumi Sawa,Junken Aoki,Masaru Ishii,Naoki Mochizuki +18 more
TL;DR: It is shown that in mice, the S1P transporter spinster homolog 2 (Spns2) is responsible for the egress of mature T cells and immature B cells from the thymus and bone marrow, respectively, and that Spns2 functions in ECs to establish the S 1P gradient required for T and B cells to egress from their respective primary lymphoid organs.
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Hypertension Induced in Pregnant Mice by Placental Renin and Maternal Angiotensinogen
Eriko Takimoto,Junji Ishida,Fumihiro Sugiyama,Hisashi Horiguchi,Kazuo Murakami,Akiyoshi Fukamizu +5 more
TL;DR: Maternal hypertension was studied in an animal model by mating transgenic mice expressing components of the human renin-angiotensin system, which may provide molecular insights into pregnancy-associated hypertension in humans.