Junjun Zhang

TL;DR: A first-generation CNV map of the human genome is constructed through the study of 270 individuals from four populations with ancestry in Europe, Africa or Asia, underscoring the importance of CNV in genetic diversity and evolution and the utility of this resource for genetic disease studies.

TL;DR: Systematic studies of more than 25,000 cancer genomes will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: The organization, functionality, and capabilities of the ICGC Data Portal are described, which allows each ICGC member institution to manage and maintain its own databases locally, while seamlessly presenting all the data in a single access point for users.

TL;DR: BioMart Central Portal offers a one-stop shop solution to access a wide array of biological databases such as Ensembl, Uniprot, Reactome, HGNC, Wormbase and PRIDE making cross querying of these data sources in a user friendly and unified way.