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Author

Jurairat Nunthanid

Other affiliations: Mahidol University
Bio: Jurairat Nunthanid is an academic researcher from Silpakorn University. The author has contributed to research in topics: Shellac & Chitosan. The author has an hindex of 30, co-authored 63 publications receiving 3027 citations. Previous affiliations of Jurairat Nunthanid include Mahidol University.
Topics: Shellac, Chitosan, Dosage form, Drug carrier, Swelling


Papers
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Journal ArticleDOI
TL;DR: The higher the degree of deacetylation of chitosan the more brittle and the less moisture absorption the films became, and transmission infrared and 13C-NMR spectra supported that Chitosonium acetate films prepared by a casting technique using acetic acid as a dissolving vehicle were chitOSoniumacetate films.
Abstract: Chitosan films, varying in molecular weight and degree of deacetylation, were prepared by a casting technique using acetic acid as a dissolving vehicle. The physicochemical properties of the films were characterized. Both molecular weight and degree of deaceylation affected the film properties. Powder X-ray diffraction patterns and differential scanning calorimetry thermograms of all chitosan films indicated their amorphous state to partially crystalline state with thermal degradation temperature lower than 280-300 degrees C. The increase in molecular weight of chitosan would increase the tensile strength and elongation as well as moisture absorption of the films, whereas the increase in degree of deacetylation of chitosan would either increase or decrease the tensile strength of the films depending on its molecular weight. Moreover, the higher the degree of deacetylation of chitosan the more brittle and the less moisture absorption the films became. All chitosan films were soluble in HCl-KCl buffer (pH 1.2), normal saline, and distilled water. They swelled in phosphate buffer (pH 7.4), and cross-linking between chitosan and phosphate anions might occur Finally, transmission infrared and 13C-NMR spectra supported that chitosan films prepared by using acetic acid as a dissolving were chitosonium acetate films.

300 citations

Journal ArticleDOI
TL;DR: It was suggested that the swelling property, dissolution characteristics of the polymer films, pK(a) of drugs and especially drug-polymer interaction were important factors governing drug release patterns from chitosan films.

224 citations

Journal ArticleDOI
TL;DR: Pectin can be used as a mucoadhesive carrier for GI-mucoad adhesive drug delivery systems, and higher degree of esterification and molecular weight gave a stronger muco adhesion.

223 citations

01 Jan 2007
TL;DR: In this article, the performance of various pectins with different degrees of esterification and molecular weights was examined with porcine gastrointestinal (GI) mucosa, i.e. buccal, stomach, small intestine and large intestine, using a texture analyzer equipped with a mucoadhesive platform.
Abstract: Mucoadhesive performance of various pectins with different degrees of esterification and molecular weights was examined with porcine gastrointestinal (GI) mucosa, i.e. buccal, stomach, small intestine and large intestine, using a texture analyzer equipped with mucoadhesive platform. The instrumental parameters and test conditions such as pre-hydration time of pectin disc, contact time, contact force, test speed of probe withdrawal, GI tissue and test medium were also studied. Two parameters derived from texture analysis, namely maximum detachment force (Fmax) and work of adhesion (Wad), were used as parameters for comparison of mucoadhesive performance. The results indicated that degree of hydration of pectin disc affected the mucoadhesive properties. The mucoadhesion of pectin increased with the increased contact time and contact force, but not by the increased probe withdrawal speed. Tissue from different parts of GI tract and test medium also influenced the mucoadhesion. Pectins showed a stronger mucoadhesion on large intestinal mucosa than on small intestinal mucosa. The mucoadhesive properties of pectins on gastric mucosa depended on pH of the medium; a higher Fmax and Wad in a pH 4.8 medium than a pH 1.2 medium was revealed. Additionally, pectin showed a significantly higher mucoadhesion than carbomer934P in most of the GI mucosa tested. The results also demonstrated that the mucoadhesive performance of pectins largely depended on their characteristics, i.e. higher degree of esterification and molecular weight gave a stronger mucoadhesion. These findings suggest that pectin can be used as a mucoadhesive carrier for GI-mucoadhesive drug delivery systems. � 2007 Elsevier B.V. All rights reserved.

206 citations

Journal ArticleDOI
TL;DR: In this article, the authors investigated the effect of pectin-based hydrophilic matrix tablets on drug release and showed that the extent of matrix swelling, erosion and diffusion of drugs determined the kinetics as well as mechanism of drug release from pectina-based matrix tablets.

182 citations


Cited by
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Journal Article
TL;DR: This book by a teacher of statistics (as well as a consultant for "experimenters") is a comprehensive study of the philosophical background for the statistical design of experiment.
Abstract: THE DESIGN AND ANALYSIS OF EXPERIMENTS. By Oscar Kempthorne. New York, John Wiley and Sons, Inc., 1952. 631 pp. $8.50. This book by a teacher of statistics (as well as a consultant for \"experimenters\") is a comprehensive study of the philosophical background for the statistical design of experiment. It is necessary to have some facility with algebraic notation and manipulation to be able to use the volume intelligently. The problems are presented from the theoretical point of view, without such practical examples as would be helpful for those not acquainted with mathematics. The mathematical justification for the techniques is given. As a somewhat advanced treatment of the design and analysis of experiments, this volume will be interesting and helpful for many who approach statistics theoretically as well as practically. With emphasis on the \"why,\" and with description given broadly, the author relates the subject matter to the general theory of statistics and to the general problem of experimental inference. MARGARET J. ROBERTSON

13,333 citations

Journal ArticleDOI
Zonghua Liu1, Yanpeng Jiao1, Wang Yifei1, Changren Zhou1, Ziyong Zhang1 
TL;DR: In this review, four mechanisms are introduced to prepare polysaccharides-based nanoparticles, that is, covalent crosslinking, ionic crossl linking, polyelectrolyte complex, and the self-assembly of hydrophobically modified poly Saccharides.

1,508 citations

Journal ArticleDOI
TL;DR: The ability of employing zeta potential to target drug delivery systems to, and drug release at specific sites of the body are discussed.
Abstract: The zeta potential (ZP) of colloidal systems and nano-medicines, as well as their particle size exert a major effect on the various properties of nano-drug delivery systems. Not only the stability of dosage forms and their release rate are affected but also their circulation in the blood stream and absorption into body membranes are dramatically altered by ZP. In this paper the effect of ZP on the various properties of nano-medicines are reviewed. Furthermore, the ability of employing zeta potential to target drug delivery systems to, and drug release at specific sites of the body are discussed.

1,276 citations

Journal ArticleDOI
TL;DR: The net cationicity as well as the presence of multiple reactive functional groups in the molecule make chitosan a sought-after biomolecule and offers scope for manipulation for preparing a broad spectrum of derivatives for specific end use applications in diversified areas.
Abstract: Use of natural biopolymers for diversified applications in life sciences has several advantages, such as availability from replenishable agricultural or marine food resources, biocompatibility, biodegradability, therefore leading to ecological safety and the possibility of preparing a variety of chemically or enzymatically modified derivatives for specific end uses. Polysaccharides, as a class of natural macromolecules, have the tendency to be extremely bioactive, and are generally derived from agricultural feedstock or crustacean shell wastes. Cellulose, starch, pectin, etc. are the biopolymers derived from the former while chitin and chitosan are obtained from the latter. In terms of availability, chitin is next to cellulose, available to the extent of over 10 gigatons annually. The application potential of chitosan, a deacetylated derivative of chitin, is multidimensional, such as in food and nutrition, biotechnology, material science, drugs and pharmaceuticals, agriculture and environmental protection, and recently in gene therapy too. The net cationicity as well as the presence of multiple reactive functional groups in the molecule make chitosan a sought-after biomolecule. The latter offers scope for manipulation for preparing a broad spectrum of derivatives for specific end use applications in diversified areas. The biomedical and therapeutic significance of chitin/chitosan derivatives is a subject of significant concern to many all over the world. An attempt is made in this overview to consolidate some of the recent findings on the biorelated application potential of chitosan and its derivatives.

1,011 citations

Journal ArticleDOI
TL;DR: In this article, a chitosan/starch composite film was used to evaluate the tensile strength (TS), elongation-at-break (E ), and water vapor transmission rate (WVTR) of the composite film.

725 citations