J
Juraj Adamik
Researcher at University of Pittsburgh
Publications - 12
Citations - 2714
Juraj Adamik is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Medicine & Chromatin immunoprecipitation. The author has an hindex of 6, co-authored 7 publications receiving 2053 citations. Previous affiliations of Juraj Adamik include Duquesne University.
Papers
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Journal ArticleDOI
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Gillian M. Tannahill,Anne M. Curtis,Juraj Adamik,Eva M. Palsson-McDermott,Anne F. McGettrick,Gautam Goel,Christian Frezza,Nicholas J. Bernard,Beth Kelly,Niamh Foley,Liang Zheng,A. Gardet,Zhen Tong,S. S. Jany,Sinéad C. Corr,Moritz Haneklaus,Brian E. Caffrey,Kerry A. Pierce,Sarah R. Walmsley,F. C. Beasley,Eoin P. Cummins,Victor Nizet,Moira K. B. Whyte,Cormac T. Taylor,Hening Lin,Seth L. Masters,Eyal Gottlieb,Vincent P. Kelly,Clary B. Clish,Philip E. Auron,Ramnik J. Xavier,Ramnik J. Xavier,Luke A. J. O'Neill +32 more
TL;DR: The authors showed that inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1β but not tumour-necrosis factor-α in mouse macrophages.
Journal ArticleDOI
EZH2 or HDAC1 Inhibition Reverses Multiple Myeloma-Induced Epigenetic Suppression of Osteoblast Differentiation
Juraj Adamik,Shunqian Jin,Quanhong Sun,Peng Zhang,Kurt R. Weiss,Judith L. Anderson,Rebecca Silbermann,G. David Roodman,G. David Roodman,Deborah L. Galson +9 more
TL;DR: This study suggests that therapeutically targeting EZH2 or HDAC1 activity may reverse the profound multiple myeloma–induced osteoblast suppression and allow repair of the lytic lesions.
EZH2 or HDAC1 Inhibition Reverses Multiple Myeloma-Induced Epigenetic Suppression of Osteoblast Differentiation
Juraj Adamik,Shunqian Jin,Quanhong Sun,Peng Zhang,Kurt R. Weiss,Judith L. Anderson,Rebecca Silbermann,G. David Roodman,G. David Roodman,Deborah L. Galson +9 more
TL;DR: In this paper, chromatin immunoprecipitation analyses reveal that multiple myeloma cells induce repressive epigenetic histone changes at the Runx2 locus that prevent osteoblast differentiation.
Journal ArticleDOI
The Role of Semaphorin 4D in Bone Remodeling and Cancer Metastasis.
Konstantinos Lontos,Juraj Adamik,Anastasia Tsagianni,Deborah L. Galson,John M. Chirgwin,Attaya Suvannasankha +5 more
TL;DR: Sem4D (Sema4D; CD100) is a transmembrane homodimer 150-kDa glycoprotein member of the Semaphorin family as discussed by the authors.
Journal ArticleDOI
Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α
Juraj Adamik,Kent Z.Q. Wang,Sebnem Unlu,An-Jey A. Su,Gillian M. Tannahill,Deborah L. Galson,Luke A. J. O'Neill,Philip E. Auron,Philip E. Auron +8 more
TL;DR: Differences in induction mechanisms argue against the prevailing paradigm that all IE genes possess paused Pol II and may further delineate the specific roles played by each of these rapidly expressed immune modulators.