Jürgen-Hinrich Fuhrhop

Bio: Jürgen-Hinrich Fuhrhop is an academic researcher from Free University of Berlin. The author has contributed to research in topics: Porphyrin & Monolayer. The author has an hindex of 35, co-authored 208 publications receiving 5130 citations. Previous affiliations of Jürgen-Hinrich Fuhrhop include Fritz Haber Institute of the Max Planck Society & Technical University of Berlin.

The chiral bilayer effect stabilizes micellar fibers

Abstract: Dihelical fibers several micrometers in length and gels were obtained by spontaneous aggregation of octyl L- and D-gluconamides. The single strands have the thickness of a bimolecular layer. No fibers are formed from the racemate. The tendency of the chiral amphiphiles to aggregate to very long fibers instead of three-dimensional crystals is rationalized with a “chiral bilayer effect”. This effect is caused by the slowness of rearrangements from tail-to-tail hydrophobic bilayers to crystals, in which the molecular sheets are arranged in a head-to-tail fashion. Thermograms which indicate slow rearrangements in ageing gels are also reported.

High-Yield Preparation of Oligomeric C-Type DNA Toroids and Their Characterization by Cryoelectron Microscopy

Abstract: The quantitative and reversible compaction of open circular plasmid DNA (7676 bp) into toroids containing one to 19 molecules by sequential treatment with spermine and an excess of uranyl acetate is reported The toroidal DNA structure was proven by cryoelectron microscopy Linearized and supercoiled variants of the DNA also gave toroids under these conditions, but yields were significantly lower In the presence of spermine alone no toroids were found Open circular plasmid B-DNA helix was converted into the C-type helical form upon compaction as was shown by CD spectroscopy (negative peak at 255 nm) and electron microscopy (18-nm interduplex distance instead of 29 nm) Addition of uranyl salt to the DNA−spermine complexes resulted in the formation of netlike assemblies which further compacted to give toroids A model containing a hexagonal arrangement of DNA strands with extensive strand crossings is proposed Curvature and thus toroid formation is thought to be induced by the hydrophobic DNA coating

Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology.

Abstract: Although gold is the subject of one of the most ancient themes of investigation in science, its renaissance now leads to an exponentially increasing number of publications, especially in the context of emerging nanoscience and nanotechnology with nanoparticles and self-assembled monolayers (SAMs). We will limit the present review to gold nanoparticles (AuNPs), also called gold colloids. AuNPs are the most stable metal nanoparticles, and they present fascinating aspects such as their assembly of multiple types involving materials science, the behavior of the individual particles, size-related electronic, magnetic and optical properties (quantum size effect), and their applications to catalysis and biology. Their promises are in these fields as well as in the bottom-up approach of nanotechnology, and they will be key materials and building block in the 21st century. Whereas the extraction of gold started in the 5th millennium B.C. near Varna (Bulgaria) and reached 10 tons per year in Egypt around 1200-1300 B.C. when the marvelous statue of Touthankamon was constructed, it is probable that “soluble” gold appeared around the 5th or 4th century B.C. in Egypt and China. In antiquity, materials were used in an ecological sense for both aesthetic and curative purposes. Colloidal gold was used to make ruby glass 293 Chem. Rev. 2004, 104, 293−346

Exploitation of Localized Surface Plasmon Resonance

Abstract: Recent advances in the exploitation of localized surface plasmons (charge density oscillations confined to metallic nanoparticles and nanostructures) in nanoscale optics and photonics, as well as in the construction of sensors and biosensors, are reviewed here. In particular, subsequent to brief surveys of the most-commonly used methods of preparation and arraying of materials with localized surface plasmon resonance (LSPR), and of the optical manifestations of LSPR, attention will be focused on the exploitation of metallic nanostructures as waveguides; as optical transmission, information storage, and nanophotonic devices; as switches; as resonant light scatterers (employed in the different near-field scanning optical microscopies); and finally as sensors and biosensors.

Integrated Nanoparticle–Biomolecule Hybrid Systems: Synthesis, Properties, and Applications

Abstract: Nanomaterials, such as metal or semiconductor nanoparticles and nanorods, exhibit similar dimensions to those of biomolecules, such as proteins (enzymes, antigens, antibodies) or DNA. The integration of nanoparticles, which exhibit unique electronic, photonic, and catalytic properties, with biomaterials, which display unique recognition, catalytic, and inhibition properties, yields novel hybrid nanobiomaterials of synergetic properties and functions. This review describes recent advances in the synthesis of biomolecule-nanoparticle/nanorod hybrid systems and the application of such assemblies in the generation of 2D and 3D ordered structures in solutions and on surfaces. Particular emphasis is directed to the use of biomolecule-nanoparticle (metallic or semiconductive) assemblies for bioanalytical applications and for the fabrication of bioelectronic devices.

Palladium-catalyzed cross-coupling reactions in total synthesis.

Abstract: In studying the evolution of organic chemistry and grasping its essence, one comes quickly to the conclusion that no other type of reaction plays as large a role in shaping this domain of science than carbon-carbon bond-forming reactions. The Grignard, Diels-Alder, and Wittig reactions are but three prominent examples of such processes, and are among those which have undeniably exercised decisive roles in the last century in the emergence of chemical synthesis as we know it today. In the last quarter of the 20th century, a new family of carbon-carbon bond-forming reactions based on transition-metal catalysts evolved as powerful tools in synthesis. Among them, the palladium-catalyzed cross-coupling reactions are the most prominent. In this Review, highlights of a number of selected syntheses are discussed. The examples chosen demonstrate the enormous power of these processes in the art of total synthesis and underscore their future potential in chemical synthesis.