J
Jurgens Nortje
Researcher at University of Cambridge
Publications - 32
Citations - 2333
Jurgens Nortje is an academic researcher from University of Cambridge. The author has contributed to research in topics: Traumatic brain injury & Intracranial pressure. The author has an hindex of 21, co-authored 29 publications receiving 2019 citations. Previous affiliations of Jurgens Nortje include Norwich University.
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Journal ArticleDOI
Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients
Ivan Timofeev,Keri L.H. Carpenter,Jurgens Nortje,Pippa G. Al-Rawi,M. T. O’Connell,Marek Czosnyka,Peter Smielewski,John D. Pickard,David K. Menon,Peter J. Kirkpatrick,Arun K. Gupta,Peter J. Hutchinson +11 more
TL;DR: The results of this study suggest that extracellular metabolic markers are independently associated with outcome following traumatic brain injury and whether treatment-related improvement in biochemistry translates into better outcome remains to be established.
Journal ArticleDOI
Traumatic brain injury: physiology, mechanisms, and outcome.
Jurgens Nortje,David K. Menon +1 more
TL;DR: There is a gathering body of work that highlights the outcome impact of subtle neurocognitive changes, which may not be quantified adequately by outcome measures used in previous trials.
Journal ArticleDOI
Effect of decompressive craniectomy on intracranial pressure and cerebrospinal compensation following traumatic brain injury.
Ivan Timofeev,Marek Czosnyka,Jurgens Nortje,Peter Smielewski,Peter J. Kirkpatrick,Arun K. Gupta,Peter J. Hutchinson +6 more
TL;DR: In this study, decompressive craniectomy led to a sustained reduction in ICP and improvement in cerebral compliance, and derangement in cerebrovascular pressure reactivity requires further studies to evaluate its significance and influence on outcome.
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Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra.
Peter J. Hutchinson,M. T. O’Connell,Nancy J. Rothwell,Stephen J. Hopkins,Jurgens Nortje,Keri L.H. Carpenter,Ivan Timofeev,Pippa G. Al-Rawi,David K. Menon,John D. Pickard +9 more
TL;DR: Feelings of feasibility of the microdialysis methodology in recovering IL-1 family cytokines for assessing their inter-relationships in the injured human brain are demonstrated, and a neuroprotective role forIL-1ra is suggested.
Journal ArticleDOI
The effect of red blood cell transfusion on cerebral oxygenation and metabolism after severe traumatic brain injury.
David A. Zygun,Jurgens Nortje,Peter J. Hutchinson,Ivan Timofeev,David K. Menon,Arun Kumar Gupta +5 more
TL;DR: Transfusion of packed red blood cells acutely results in improved brain tissue oxygen without appreciable effect on cerebral metabolism.