J
Justin C. McArthur
Researcher at Johns Hopkins University School of Medicine
Publications - 437
Citations - 50107
Justin C. McArthur is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Dementia & Acquired immunodeficiency syndrome (AIDS). The author has an hindex of 113, co-authored 433 publications receiving 47346 citations. Previous affiliations of Justin C. McArthur include University of Rochester & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Updated research nosology for HIV-associated neurocognitive disorders
Andrea Antinori,Gabriele Arendt,James T. Becker,Bruce J. Brew,Desiree Byrd,Mariana Cherner,David B. Clifford,Paola Cinque,Leon G. Epstein,K. Goodkin,Magnus Gisslén,Igor Grant,Robert K. Heaton,Jeymohan Joseph,Karen Marder,Camillo Marra,Justin C. McArthur,Michael Nunn,Richard W. Price,Lynn Pulliam,Kevin Robertson,Ned Sacktor,Victor Valcour,Valerie Wojna +23 more
TL;DR: This report reviews the collective experience with HIV-associated neurocognitive disorders (HAND), particularly since the advent of highly active antiretroviral treatment, and their definitional criteria; discusses the impact of comorbidities; and suggests inclusion of the term asymptomatic neuroc cognitive impairment to categorize individuals with subclinical impairment.
Journal ArticleDOI
HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study.
Robert K. Heaton,David B. Clifford,Donald Franklin,Steven Paul Woods,Christopher Ake,Florin Vaida,Ronald J. Ellis,S. Letendre,Thomas D. Marcotte,Joseph H. Atkinson,Monica Rivera-Mindt,Ofilio Vigil,Michael J. Taylor,Ann C. Collier,Camillo Marra,Benjamin B. Gelman,Justin C. McArthur,Susan Morgello,David M. Simpson,McCutchan Ja,Ian Abramson,Anthony Gamst,Christine Fennema-Notestine,Terry L. Jernigan,Joseph K. Wong,Igor Grant +25 more
TL;DR: The most severe HAND diagnosis (HAD) was rare, but milder forms of impairment remained common, even among those receiving CART who had minimal comorbidities.
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HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors
Robert K. Heaton,Donald Franklin,Ronald J. Ellis,J. Allen McCutchan,Scott Letendre,Shannon LeBlanc,Stephanie Corkran,Nichole A. Duarte,David B. Clifford,Steven Paul Woods,Ann C. Collier,Christina M. Marra,Susan Morgello,Monica Rivera Mindt,Michael J. Taylor,Thomas D. Marcotte,J. Hampton Atkinson,Tanya Wolfson,Benjamin B. Gelman,Justin C. McArthur,David M. Simpson,Ian Abramson,Anthony Gamst,Christine Fennema-Notestine,Terry L. Jernigan,Joseph K. Wong,Igor Grant +26 more
TL;DR: In this article, the authors used comparable methods of subject screening and assessments to classify neurocognitive impairment (NCI) in large groups of HIV + and HIV − participants from the pre-CART era (1988-1995, N = 857) and CART era(2000-2007; N = 937).
Journal ArticleDOI
Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system.
Scott Letendre,Jennifer Marquie-Beck,Edmund V. Capparelli,Brookie M. Best,David B. Clifford,Ann C. Collier,Benjamin B. Gelman,Justin C. McArthur,J. Allen McCutchan,Susan Morgello,David M. Simpson,Igor Grant,Ronald J. Ellis +12 more
TL;DR: Poorer penetration of ARV drugs into the CNS appears to allow continued HIV replication in the CNS as indicated by higher CSF HIV viral loads, which is probably critical in treating patients who have HIV-associated neurocognitive disorders.
Journal ArticleDOI
Nomenclature and research case definitions for neurologic manifestations of human immunodeficiency virus-type 1 (HIV-1) infection
Robert S. Janssen,David R. Cornblath,Leon G. Epstein,Richard P. Foa,Justin C. McArthur,Richard W. Price,Arthur K. Asbury,Alexandra Beckett,D. Frank Benson,T.Peter Bridge,Carl M. Leventhal,Paul Satz,Andrew J. Saykin,John J. Sidtis,Susan Tross,James T. Becker,Kenneth G. Castro,Bruce A. Cohen,Marshall F. Folstein,Francisco Gonzalez-Scarano,Igor Grant,Mario Maj,R. H. McAllister,M.-Marsel Mesulam,Eric N. Miller,Margaret J. Oxtoby,Norman Sartorius,Ola A. Selnes,Janet B. W. Williams,Michael Zaudig +29 more
TL;DR: These definitions have been developed in conjunction with the International Classification of Diseases-10 (ICD-10, unpublished draft of the World Health Organization) and the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV, unpublishedDraft of the American Psychiatric Association) and are not identical.