Author
Justo Cobo
Bio: Justo Cobo is an academic researcher from University of Jaén. The author has contributed to research in topics: Hydrogen bond & Molecule. The author has an hindex of 26, co-authored 484 publications receiving 3148 citations.
Topics: Hydrogen bond, Molecule, Ring (chemistry), Pyrazole, Aryl
Papers published on a yearly basis
Papers
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TL;DR: Several novel compounds synthesized from a Claisen-Schmidt reaction of 3-aryl-1-phenylpyrazol-4-carboxaldehydes 4 with several acetophenone derivatives were screened by the US National Cancer Institute for their ability to inhibit 60 different human tumor cell lines.
192 citations
TL;DR: Novel quinoline-2-one based chalcones were synthesized from a Claisen-Schmidt condensation by using the couple KOH/1,4-dioxane as reaction medium and may possibly be used as lead compound for developing new anticancer agents.
111 citations
TL;DR: A new series of N-acetyl and N-formyl-pyrazoline derivatives 6 and 7-8 showed remarkable antitumor activity against cancer cell lines, with the most important GI50 values ranging from 0.13 to 0.99 μM.
108 citations
TL;DR: In this paper, a tricyclic linear 3,7,7-trimethyl-4, 7, 8, 9-tetrahydro-2H-pyrazolo[3,4-b]quinolin-5(6H)-one with dimedone and aldehydes was obtained.
91 citations
TL;DR: Novel methyl 1-tert-butyl-1-pyrazol-3-yl)-2-(aryl)-1H-benzo[d]imidazole-5-carboxylates 11 were synthesized by following a four-step strategy involving a nucleophilic aromatic displacement (S(N)Ar) and a solvent free approach as key steps for the formation of the desired products.
81 citations
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785 citations
663 citations
TL;DR: 1. Six-Membered Heterocycles with One Heteroatom 4155 7.6.1.
Abstract: 6.1. Oxadiazoles 4154 6.2. Diazaphospholes 4154 7. Six-Membered Heterocycles with One Heteroatom 4155 7.1. Pyridines 4155 7.2. Pyridinones 4155 7.3. Quinolines 4156 7.4. Quinolinones 4157 7.5. Isoquinolines 4157 7.6. Acridines 4158 7.7. Pyranones 4158 7.8. Flavones 4159 8. Six-Membered Heterocycles with Two Heteroatoms 4159 8.1. Pyridazinones 4159 8.2. Pyrimidines 4159 8.3. Pyrimidinones 4160 8.4. Quinazolines 4162 8.5. Quinazolinones 4162 8.6. Quinoxalines 4164 8.7. Quinoxalinediones 4165 8.8. Oxazines 4165 8.9. Oxazinones 4166 8.10. Thiazines 4166 9. Six-Membered Heterocycles with Three Heteroatoms 4166
549 citations
TL;DR: This review has compiled and discussed specifically the anticancer potential of quinoline derivatives, which could provide a low-height flying bird's eye view of theQuinoline derived compounds to a medicinal chemist for a comprehensive and target oriented information for development of clinically viable anticancer drugs.
530 citations