Jyoti R. Kavali

Bio: Jyoti R. Kavali is an academic researcher from Karnatak University. The author has contributed to research in topics: Aryl & Triazole. The author has an hindex of 2, co-authored 5 publications receiving 45 citations.

1,5-Benzodiazepine derivatives of 3-arylsydnones: synthesis and antimicrobial activity of 3-aryl-4-[2′-aryl-2′,4′,6′,7′-tetrahydro-(1′H)-1′,5′-benzodiazepine-4′-yl]sydnones

Abstract: The α-β-unsaturated ketones of 3-arylsydnones (Ia–y) were treated with 1,2-phenylenediamine to obtain the 3-aryl-4-[2′-aryl-2′,4′,6′,7′-tetrahydro-(1′H)-1′,5′-benzodiazepine-4′-yl]sydnones (IIa–y) in high yield. All the new compounds synthesised were screened for antibacterial and antifungal activities.

Synthetic utility of 4-acetyl-3-arylsydnones: Synthesis, spectral characterisation and antimicrobial activity of 3-aryl-4-[(2′,3′-dihydrospiro-1′,4′-benzodiazepine-5′,[3″-3″H]-2″-oxindol]-(1″H))-7′-yl] sydnones

Abstract: 3-Aryl-4-[3′-hydroxy-2'oxo)-3′-indol]acetylsydnones IIa–n have been synthesised from 4-acetyl-3-arylsdnones Ia–n and isatin. These β-hydroxy derivatives were readily converted into the corresponding α, β-unsaturated ketones IIIa–n which were further condensed with 1,2-phenylenediamine to give the 3-aryl-4-[2′,3′-dihydrospiro-1′,4′-benzodiazepine-5′,3″-[3″H]-2″-oxindol-)1″H))-7′-yl]sydnones IVa–n. All the compounds have been evaluated for their in vitro growth inhibitory activity against few microbes.

4‐Amino‐2‐(p‐chloro­phenyl)‐5‐methyl‐3,4‐di­hydro‐2H‐1,2,4‐triazol‐3‐one

Abstract: In the title compound, C9H9ClN4O, the dihedral angle between the substituted phenyl and triazole rings is 4.86 (5)°. In the crystalline state, the mol­ecules exist as centrosymmetrically related N—H⋯O hydrogen-bonded dimers.

1,5‐Benzodiazepine Derivatives of 3‐Arylsydnones: Synthesis and Antimicrobial Activity of 3‐Aryl‐4‐[2′‐aryl‐2′,4′,6′,7′‐tetrahydro‐ (1′H)‐1′,5′‐benzodiazepine‐4′‐yl]sydnones.

Abstract: The α-β-unsaturated ketones of 3-arylsydnones (Ia–y) were treated with 1,2-phenylenediamine to obtain the 3-aryl-4-[2′-aryl-2′,4′,6′,7′-tetrahydro-(1′H)-1′,5′-benzodiazepine-4′-yl]sydnones (IIa–y) in high yield. All the new compounds synthesised were screened for antibacterial and antifungal activities.

Coupling-isomerization-N,S-ketene acetal-addition sequences--a three-component approach to highly fluorescent pyrrolo[2,3-b]pyridines, [1,8]naphthyridines, and pyrido[2,3-b]azepines.

Abstract: Annelated 2-amino pyridines such as pyrrolo[2,3-b]pyridines, [1,8]naphthyridines, and pyrido[2,3-b]azepines can be synthesized in moderate to good yields in a consecutive one-pot three-component process by a coupling-isomerization-enamine-addition-cyclocondensation sequence of an electron-poor (hetero)aryl halide, a terminal propargyl N-tosylamine, and an N,S-ketene acetal. After the coupling-isomerization sequence, a Diels-Alder reaction with inverse electron demand of the intermediate enimine and the N,S-ketene acetal and subsequent aromatization furnish annelated 2-amino pyridines 4 that were unambiguously characterized by numerous X-ray structure analyses. These heterocycles are highly fluorescent and partially pH sensitive, and their electronic structure was studied with spectroscopic and computational methods.