The ascending monoamine pathways in the rat brain are demonstrated by the pile up of fluorescent material occurring in the axons after various types of lesions. The anatomy of the pathways is outlined in drawings of frontal sections of the brain and the origin and termination of several pathways is determined by studying the anterograde and retrograde degeneration occurring after well localised lesions. It is possible to separate the ascending NA pathways into a dorsal and a ventral bundle of axons. The dorsal bundle innervates the cortex and the hippocampus and the ventral bundle supplies NA nerve terminals to the medulla, the pons, the mesencephalon and the diencephalon. The dorsal bundle is found to originate in the locus coeruleus. Lesions of this nucleus abolish the nerve terminals in all cortical areas and in several other areas of the brain indicating a unique role for the locus coeruleus in influencing the activity of the entire brain. The 5-HT pathways have a distribution similar to the ventral NA pathyway. The course of the nigro-striatal and the meso-limbic DA pathways is presented in detail.

Stereotaxic mapping of the monoamine pathways in the rat brain.

Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals.

Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors.

Hypothalamic Integration: Organization of the Paraventricular and Supraoptic Nuclei

Nucleus locus ceruleus: new evidence of anatomical and physiological specificity

Evidence for the existence of monoamine neurons in the central nervous system. iv. distribution of monoamine nerve terminals in the central nervous system.

K Fuxe

Papers

Evidence for the existence of monoamine neurons in the central nervous system. iv. distribution of monoamine nerve terminals in the central nervous system.