K
K. Kent
Researcher at National Institute for Biological Standards and Control
Publications - 13
Citations - 790
K. Kent is an academic researcher from National Institute for Biological Standards and Control. The author has contributed to research in topics: Simian immunodeficiency virus & Virus. The author has an hindex of 11, co-authored 13 publications receiving 786 citations.
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Journal ArticleDOI
Protection by attenuated simian immunodeficiency virus in macaques against challenge with virus-infected cells
TL;DR: Findings show that live-attenuated vaccine can confer protection against SIV in macaques, and the mechanism of this potent protection must be understood and reproduced by less hazardous means.
Journal ArticleDOI
Evasion of Cytotoxic T Lymphocyte (CTL) Responses by Nef-dependent Induction of Fas Ligand (CD95L) Expression on Simian Immunodeficiency Virus–infected Cells
Xiao-Ning Xu,Gavin R. Screaton,Frances Gotch,Tao Dong,Rusung Tan,Neil Almond,Barry Walker,Richard Stebbings,K. Kent,Shigekazu Nagata,Jim Stott,Andrew J. McMichael +11 more
TL;DR: Interruption of the Fas-FasL interaction allows the regeneration of viral-specific CTL responses in pJ5-infected animals, suggesting an additional therapeutic approach to the treatment of AIDS.
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Production and of monoclonal antibodies to simian immunodeficiency virus envelope glycoproteins.
K. Kent,L Gritz,G Stallard,Martin Cranage,C. Collignon,C. Thiriart,T. Corcoran,P. Silvera,E.J. Stott +8 more
TL;DR: Although similar titres were obtained with some MAb against other SIV and HIV antigens, the presence of isolate specific and shared group epitopes was demonstrated and the neutralizing MAb did not react with denatured antigen in Western blot suggesting that they may recognize conformational epitopes.
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Immunization with class I human histocompatibility leukocyte antigen can protect macaques against challenge infection with SIVmac-32H.
Woon Ling Chan,Angela Rodgers,Chris Grief,Neil Almond,Sally Ellis,Brian Flanagan,P. Silvera,Janet S. Bootman,James Stott,K. Kent,Robert Bomford +10 more
TL;DR: This demonstration of partial protection against SIV infection with SIV grown in simian cells suggests that allogenic immune response induced before or during establishment of HIV infection may have important implications for AIDS disease progression.
Journal ArticleDOI
Passive immunization of cynomolgus macaques with immune sera or a pool of neutralizing monoclonal antibodies failed to protect against challenge with SIVmac251.
K. Kent,P. Kitchin,Kingston H. G. Mills,Mark Page,Frank Taffs,T. Corcoran,P. Silvera,B. Flanagan,C. Powell,J. Rose,C Ling,A. M. Aubertin,E.J. Stott +12 more
TL;DR: The results suggest that in this model the presence of circulating neutralizing antibodies alone does not necessarily confer protection against challenge with SIVmac251 grown in simian cells.