K
K. Le Blanc
Researcher at Karolinska University Hospital
Publications - 53
Citations - 23007
K. Le Blanc is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Mesenchymal stem cell & Stem cell. The author has an hindex of 25, co-authored 41 publications receiving 20533 citations. Previous affiliations of K. Le Blanc include Karolinska Institutet.
Papers
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Journal ArticleDOI
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
Massimo Dominici,K. Le Blanc,Ingo Mueller,I. Slaper-Cortenbach,Frank C. Marini,Diane S. Krause,Robert J. Deans,Armand Keating,Darwin J. Prockop,Edwin M. Horwitz +9 more
TL;DR: The Mesenchymal and Tissue Stem Cell Committee of the International Society for Cellular Therapy proposes minimal criteria to define human MSC, believing this minimal set of standard criteria will foster a more uniform characterization of MSC and facilitate the exchange of data among investigators.
Journal ArticleDOI
Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement
Edwin M. Horwitz,K. Le Blanc,Massimo Dominici,Ingo Mueller,I. Slaper-Cortenbach,Frank C. Marini,Robert J. Deans,Diane S. Krause,Armand Keating +8 more
TL;DR: The mesenchymal stromal cells (MSC) as mentioned in this paper have been proposed as a more scientifically correct nomenclature for the fibroblast-like cells, regardless of the tissue from which they are isolated.
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Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex.
TL;DR: MSC added to PBL cultures had various effects, ranging from slight inhibition to stimulation of DNA synthesis, which was not affected by the MSC dose or by the addition of allogeneic or autologous MSCs to the lymphocytes.
Journal ArticleDOI
Immunomodulation by mesenchymal stem cells and clinical experience
K. Le Blanc,Olle Ringdén +1 more
TL;DR: In vivo, MSCs prolong skin allograft survival and have several immunomodulatory effects, which are presented and discussed in the present study.
Journal ArticleDOI
Immunomodulatory effects of fetal and adult mesenchymal stem cells.
TL;DR: Findings imply a potential role for MSC, not only in the repair of damaged tissues, but also in the manipulation of immune responses, as well as the transplantable between HLA-mismatched individuals without the need for host immunosuppression.