Author
K. Luan Phan
Other affiliations: University of Pittsburgh, The Ohio State University Wexner Medical Center, University of Michigan ...read more
Bio: K. Luan Phan is an academic researcher from Ohio State University. The author has contributed to research in topics: Anxiety & Prefrontal cortex. The author has an hindex of 65, co-authored 277 publications receiving 21138 citations. Previous affiliations of K. Luan Phan include University of Pittsburgh & The Ohio State University Wexner Medical Center.
Papers published on a yearly basis
Papers
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TL;DR: A critical comparison of findings across individual studies is provided and suggests that separate brain regions are involved in different aspects of emotion.
3,349 citations
TL;DR: Studies of Pavlovian fear conditioning and extinction in rodents and humans suggest that a neural circuit including the hippocampus, amygdala and medial prefrontal cortex is involved in the learning and memory processes that enable context-dependent behaviour.
Abstract: Contexts surround and imbue meaning to events; they are essential for recollecting the past, interpreting the present and anticipating the future. Indeed, the brain's capacity to contextualize information permits enormous cognitive and behavioural flexibility. Studies of Pavlovian fear conditioning and extinction in rodents and humans suggest that a neural circuit including the hippocampus, amygdala and medial prefrontal cortex is involved in the learning and memory processes that enable context-dependent behaviour. Dysfunction in this network may be involved in several forms of psychopathology, including post-traumatic stress disorder, schizophrenia and substance abuse disorders.
1,196 citations
TL;DR: It is found that males showed more lateralization of emotional activity, and females showed more brainstem activation in affective paradigms, providing evidence that lateralization in emotional activity is more complex and region-specific than predicted by previous theories of emotion and the brain.
1,118 citations
TL;DR: It is shown that activity in specific areas of the frontal cortex covaries with amygdala activity and that this functional connectivity is dependent on the reappraisal task, highlighting the importance of functional connectivity within limbic-frontal circuitry during emotion regulation.
Abstract: Successful control of affect partly depends on the capacity to modulate negative emotional responses through the use of cognitive strategies (i.e., reappraisal). Recent studies suggest the involvement of frontal cortical regions in the modulation of amygdala reactivity and the mediation of effective emotion regulation. However, within-subject inter-regional connectivity between amygdala and prefrontal cortex in the context of affect regulation is unknown. Here, using psychophysiological interaction analyses of functional magnetic resonance imaging data, we show that activity in specific areas of the frontal cortex (dorsolateral, dorsal medial, anterior cingulate, orbital) covaries with amygdala activity and that this functional connectivity is dependent on the reappraisal task. Moreover, strength of amygdala coupling with orbitofrontal cortex and dorsal medial prefrontal cortex predicts the extent of attenuation of negative affect following reappraisal. These findings highlight the importance of functional connectivity within limbic-frontal circuitry during emotion regulation.
1,029 citations
TL;DR: A functional dissociation of corticolimbic brain responses, involving enhanced activation of prefrontal cortex and attenuation of limbic areas, during volitional suppression of negative emotion is highlighted.
860 citations
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01 Jan 2016
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14,604 citations
9,362 citations
TL;DR: The results suggest a functional architecture for the cognitive control of emotion that dovetails with findings from other human and nonhuman research on emotion.
3,817 citations
3,628 citations
TL;DR: This work reviews the emerging literature that relates social cognition to the medial frontal cortex and proposes a theoretical model of medial frontal cortical function relevant to different aspects of social cognitive processing.
Abstract: Social interaction is a cornerstone of human life, yet the neural mechanisms underlying social cognition are poorly understood. Recently, research that integrates approaches from neuroscience and social psychology has begun to shed light on these processes, and converging evidence from neuroimaging studies suggests a unique role for the medial frontal cortex. We review the emerging literature that relates social cognition to the medial frontal cortex and, on the basis of anatomical and functional characteristics of this brain region, propose a theoretical model of medial frontal cortical function relevant to different aspects of social cognitive processing.
3,426 citations