K.M. Madyastha

TL;DR: It is demonstrated that phycocyanin is a potent peroxyl radical scavenger with an IC(50) of 5.0 microM and the rate constant ratios obtained for phydynamic acid and uric acid were 1.54 and 3.5, respectively, which clearly suggest that the covalently linked chromophore, phyCocyanobilin, is involved in the antioxidant and radical scavenging activity of phy cokyanin.

TL;DR: The present study points out that the hepatoprotective, anti-inflammatory, and anti-arthritic properties of phycocyanin reported in the literature may be due, in part, to its selective COX-2 inhibitory property, although its ability to efficiently scavenge free radicals and effectively inhibit lipid peroxidation may also be involved.

TL;DR: Intraperitoneal administration of a single dose of phycocyanin to rats, one or three hours prior to R-(+)-pulegone (250 mg/kg) or carbontetrachloride (0.6 ml/ kg) challenge, significantly reduced the hepatotoxicity caused by these chemicals.

TL;DR: This C-PC induced apoptosis in RAW 264.7 cells appears to be mediated by the release of cytochrome c from mitochondria and independent of Bcl-2 expression, and may be due to reduced PGE(2) levels as a result of COX-2 inhibition.

TL;DR: The unique form of aggregation of two (alphabeta)6-hexamers in the crystal asymmetric unit, suggests additional pathways of energy transfer in lateral direction between the adjacent hexamers involving beta155 phycocyanobilin chromophores.