Author
K. M. Muraleedharan
Other affiliations: University of Mississippi, Indian Institute of Chemical Technology, Council of Scientific and Industrial Research
Bio: K. M. Muraleedharan is an academic researcher from Indian Institute of Technology Madras. The author has contributed to research in topics: Artemisinin & Carboxylic acid. The author has an hindex of 12, co-authored 47 publications receiving 751 citations. Previous affiliations of K. M. Muraleedharan include University of Mississippi & Indian Institute of Chemical Technology.
Topics: Artemisinin, Carboxylic acid, Apoptosis, Reagent, Hydrogen bond
Papers
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TL;DR: In this paper, the title reagent system was used for the chemoselective epoxidation of various hydroxy group-containing electron deficient olefins, and the reaction was shown to proceed diastereoselectively if an unprotected hydroxy groups is present and non-diastereselectively in case of protected analogues.
Abstract: The title reagent system is efficiently used for the chemoselective epoxidation of various hydroxy group-containing electron deficient olefins, and the reaction is shown to proceed diastereoselectively if an unprotected hydroxy group is present and non-diastereoselectively in case of protected analogues.
1 citations
TL;DR: A new chiral system is identified which exhibits consistent and perfectly reversible chiro-optical responses on sol-gel transition that can work like an ON-OFF switch.
Abstract: Systematic structure–property optimization of an achiral gelator (aryl-triazolyl homo dipeptide, 1.0) through a fragment replacement approach led to the identification of a new chiral system (aryl-triazolyl dipeptide 1.4 having leucine as the C-terminal residue) which exhibits consistent and perfectly reversible chiro-optical responses on sol–gel transition that can work like an ON–OFF switch. The gelator 1.4 could also direct the assembly of 1.0 in a sergeant-soldier mode to give similar CD responses. In addition, its gels are mouldable, self-healing and highly thixotropic, making it important from an application standpoint.
1 citations
TL;DR: In this article, a two-step reaction proceeds through tandem aza-Michael addition, SNAr cyclization followed by oxidation with IBX, and the result is shown to be similar to ours.
Abstract: The described two-step reaction proceeds through tandem aza-Michael addition, SNAr cyclization followed by oxidation with IBX.
TL;DR: In this article, a series of N-substituted 1,2-dihydroquinolines capable of causing redox imbalance in cancer cells are presented, and detailed studies showed that these derivatives arrest the cell cycle in the G2/M phase and induce apoptosis through an intrinsic pathway characterized by loss of mitochondrial membrane potential, DNA fragmentation, cytochrome c release and activation of caspases 9 and 3.
Abstract: Redox chemotherapy: Antiproliferative activities of a series of N-substituted 1,2-dihydroquinolines capable of causing redox imbalance in cancer cells are presented. Detailed studies showed that these derivatives arrest the cell cycle in the G2/M phase and induce apoptosis through an intrinsic pathway characterized by loss of mitochondrial membrane potential, DNA fragmentation, cytochrome c release, and activation of caspases 9 and 3.
TL;DR: The complete Ru(VIII) mediated oxidation of the benzene ring of trindane 1 was contained within the framework of peripheral methylenes to yield the unfragmented product 2 as mentioned in this paper.
Abstract: The complete, Ru(VIII) mediated oxidation of the benzene ring of trindane 1 is contained within the framework of peripheral methylenes to yield the unfragmented product 2.
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Journal Article•
TL;DR: In this paper, the authors explore recent advances in the design and engineering of materials wholly or principally constructed from peptides, and focus on materials that are able to respond to changes in their environment (pH, ionic strength, temperature, light, oxidation/reduction state, presence of small molecules or the catalytic activity of enzymes) by altering their macromolecular structure.
Abstract: This article explores recent advances in the design and engineering of materials wholly or principally constructed from peptides. We focus on materials that are able to respond to changes in their environment (pH, ionic strength, temperature, light, oxidation/reduction state, presence of small molecules or the catalytic activity of enzymes) by altering their macromolecular structure. Such peptide-based responsive biomaterials have exciting prospects for a variety of biomedical and bionanotechnology applications in drug delivery, bio-sensing and regenerative medicine.
452 citations
398 citations
TL;DR: Propargylamines have been synthesized by a gold(III) salen complex-catalyzed three-component coupling reaction of aldehydes, amines, and alkynes in water in excellent yields at 40 degrees C with excellent diastereoselectivities.
311 citations
TL;DR: Evidence for each mechanism of action attributed to artemisinin includes interference with parasite transport proteins, disruption of parasite mitochondrial function, modulation of host immune function and inhibition of angiogenesis, and the evidence for each is reviewed.
298 citations
TL;DR: Preliminary investigations suggest that the chiral catalyst may serve as a bifunctional reagent by interacting with both a carboxylic acid nucleophile and NBS electrophile.
Abstract: A catalytic enantioselective syn-1,4-bromolactonization of conjugated (Z)-enynes was reported. Diastereomeric ratios >20:1 and up to 99% enantiomeric excesses were observed. Di-, tri-, and tetra-substituted bromoallenes were prepared together with lactone heterocycles efficiently and stereoselectively. Preliminary investigations suggest that the chiral catalyst may serve as a bifunctional reagent by interacting with both a carboxylic acid nucleophile and NBS electrophile.
286 citations