K.P. Lesch

TL;DR: The results demonstrate the contributions of rearing environment and genetic background, and their interaction, in a nonhuman primate model of behavioral development.

TL;DR: It is reported that mice deficient for 5-HTT (5-HTt(-/-)) developed less hypoxic pulmonary hypertension and vascular remodeling than paired 5- HTT(+/+) controls, and this data further support a key role of 5-htT in hypoxia-induced pulmonary vascular SMC proliferation and pulmonary hypertension.

TL;DR: Quantification of [35S]GTP‐γ‐S binding evoked by potent 5‐HT1 receptor agonists confirmed changes as a decrease in this parameter was noted in the DRN (−66%) and the substantia nigra (−30%) but not other brain areas in 5‐ HTT–/– vs. 5-HTT+/+ mice.

TL;DR: Preliminary data presented here highlight the importance of considering gene‐environment interactions when studying childhood risk factors for aggression, anxiety and related neuropsychiatric disorders and support the use of the nonhuman primate for studing gene by environment interactions in behavioral research.

TL;DR: The promoter of 5HT2A was screened for polymorphisms using single-strand confirmation polymorphism analysis and an A-G polymorphism at −1438 that creates an HpaII restriction site was found to be in complete linkage disequilibrium with T102C and is a candidate for the pathogenic variant in schizophrenia.