scispace - formally typeset
K

Kah-Leong Lim

Researcher at Nanyang Technological University

Publications -  136
Citations -  21119

Kah-Leong Lim is an academic researcher from Nanyang Technological University. The author has contributed to research in topics: Parkin & Parkinson's disease. The author has an hindex of 50, co-authored 126 publications receiving 18568 citations. Previous affiliations of Kah-Leong Lim include Harvard University & Agency for Science, Technology and Research.

Papers
More filters
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Daniel J. Klionsky, +235 more
- 16 Feb 2008 - 
TL;DR: A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.
Journal ArticleDOI

Parkin ubiquitinates the α-synuclein–interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

Kenny K.K. Chung, +8 more
- 01 Oct 2001 - 
TL;DR: It is shown that parkin interacts with and ubiquitinates the α-synuclein–interacting protein, synphilin-1, which provides a molecular basis for the ubiquitination of Lewy-body–associated proteins and links parkin and α- synuclein in a common pathogenic mechanism through their interaction with synphil in-1.
Journal ArticleDOI

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

Andrew B. West, +10 more
- 15 Jan 2007 - 
TL;DR: Functional and disease-associated mutations in conserved residues reveal the critical link between intrinsic guanosine triphosphatase (GTPase) activity and downstream kinase activity, suggesting a link between LRRK2Kinase activity and pathogenic mechanisms relating to neurodegeneration and supporting a gain-of-function role for L RRK2 mutations.