Kai F. Yu

TL;DR: Alterations in the levels of sFlt-1 and free PlGF were greater in women with an earlier onset of preeclampsia and in women in whom preeClampsia was associated with a small-for-gestational-age infant.

TL;DR: Rising circulating levels of soluble endoglin and ratios of sFlt1:PlGF herald the onset of preeclampsia, which was greatest among women in the highest quartile of the control distributions for both biomarkers but not for either biomarker alone.

TL;DR: Testing the hypothesis that urinary PlGF is reduced prior to onset of hypertension and proteinuria and that this reduction predicts preeclampsia found decreased urinary Pl GF at mid gestation is strongly associated with subsequent early development of preeClampsia.

TL;DR: It is suggested that circulating soluble endoglin and spil-which cause endothelial dysfunction by different mechanisms-may contribute to the development of preeclampsia.

TL;DR: A nested case control study was performed within the Calcium for Preeclampsia Prevention trial cohort of healthy nulliparous women as discussed by the authors, which was used to determine whether pre-term pregnancy is caused by microfragments of syncytial trophoblast shed into the maternal circulation that stimulate an exaggerated inflammatory response.