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Kai Li

Bio: Kai Li is an academic researcher from Fudan University. The author has contributed to research in topics: Extraversion and introversion & Psychology. The author has an hindex of 1, co-authored 1 publications receiving 5 citations.

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Journal ArticleDOI
Ling-ling Niu1, Xingtao Zhou1, Lan Ding1, Kai Li1, Qi-hua Le1, Wenqing Zhu1 
TL;DR: The morphology of sub-basal nerve fibers had not recovered completely until 1 year after surgery and the central corneal sensitivity was better in drug treated group than in no drugtreated group at 1 month after LASEK.
Abstract: Objective To evaluate the effects of protein-free calf blood extract for recovery of corneal nerve after LASEK and LSEIK. Methods A prospective, randomized, control and double-blind study was carried out from January through February 2009 at Department of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University. Forty-nine eyes of 25 patients who underwent LASEK were randomly divided into two groups. One group with 16 patients (32 eyes) was treated by protein-free calf blood extract eye gel which was defined as drug treated group and the other group with 9 patients (17 eyes) was not treated by protein-free calf blood extract eye gel which was defined as no drug treated group. Forty-four eyes of 23 patients who underwent LASIK were also randomly divided into two groups. One group with 13 patients (24 eyes) was treated by protein-free calf blood extract eye gel which was defined as drug treated group and the other group with 10 patients (20 eyes) was not treated by protein-free calf blood extract eye gel which was defined as no drug treated group. Protein-free calf blood extract eye gel was delivered in both drug treated groups 3 times per day for three months after surgery. Laser scanning confocal microscopic examinations were performed on 48 eyes in vivo. Central corneal sensitivity and tear break-up time (BUT) were tested on 93 eyes preoperatively and 1,3,6 months, and 1 year after surgery. The obtained dates in the study were analyzed using independent samples t-test, paired t-test and Mann-Whitney Test. Results The morphology oserved by confocal microscope of sub-basal nerve fibers was not different between drug treated group and no drug treated group until the last follow up after LASIK or LASEK(Z=0.0000,P=1.00)and(Z=0.0000,P=1.00). Nerve fibers with interconnections were observed in drug treated group at 3 months after LASEK. The morphology of sub-basal nerve fibers had not recovered completely until 1 year after surgery. The central corneal sensitivity was better in drug treated group than in no drug treated group at 1 month after LASEK [(4.95±0.84)μm,(3.62±1.38) μm;t=4.23,P 0.05],[(5.79±0.36)μm;t=-0.70,P>0.05]. At 6 months postoperatively, the central corneal sensitivity of drug treated group which underwent LASIK was not significantly different from pre-operation[(5.25±0.91)μm;t=-1.87, P>0.05]. No significant difference was seen in BUT between drug treated group and no drug treated group after LASEK or LASIK until 1 year after surgery[(8.13±2.18) μm,(8.76±1.64)μm;t=-0.90,P>0.05],[(7.71±2.14) μm,(7.45±2.37)μm;t=0.30,P>0.05]. Conclusion Protein-free calf blood extract could significantly promote the recovery of corneal nerve in the early period after LASEK and LASIK. Key words: Amino acids; Nucleosides; Cornea; Nerve regeneration; Keratomileusis, laser in situ; Keratectomy, subepithelial, laser-assisted

5 citations

Journal ArticleDOI
TL;DR: In this article , the authors explored the effects of personality traits on online rumor sharing during the novel coronavirus (COVID-19) pandemic and the mediating role of the fear of COVID-2019 between them.
Abstract: This study aims to explore the effects of personality traits on online rumor sharing during the novel coronavirus (COVID-19) pandemic and the mediating role of the fear of COVID-19 between them. We conducted this research using a web-based questionnaire distributed to 452 university students who were invited to fill it out. The partial least square structural equation modeling (PLS-SEM) method was used to test the data and model, with the yielded results demonstrating that three—extroversion, emotional instability, and conscientiousness—of the Big Five personality traits are positively related to a fear of COVID-19, with this fear positively affecting online rumor sharing. Moreover, fear of COVID-19 was found to act as a mediator between personality traits and online rumor sharing; thus, we can conclude that persons with high levels of extroversion, emotional instability, and conscientiousness are more likely to share rumors online due to a fear of COVID-19. This study furthers our understanding of the psychological mechanism by which personality traits influence online rumor sharing and provides references for anti-rumor campaigns taking place during the COVID-19 pandemic, as it identifies key groups and sheds light on the necessity of reducing people’s fear of COVID-19.

5 citations

Journal ArticleDOI
Jie Li, Yan Bao, Long Gao, Kai Li, M. Sun 
TL;DR: In this paper , the role of ursolic acid (UA) in the anti-obesity process was investigated in obese mice from the perspective of intestinal microbiome and metabolomics analyses, an obese mice model was established with a high-fat diet, and the effect of UA on obesity was evaluated.
Abstract: Obesity has been regarded as one of the major health problems worldwide. Studies demonstrated that ursolic acid (UA) can significantly ameliorate the progress of obesity. However, whether the effect of UA on obesity depends on the regulation of gut microbiota and metabolism is uncertain. To investigate the regulatory role of UA in obese mice from the perspective of intestinal microbiome and metabolomics analyses, an obese mice model was established with a high-fat diet, and the effect of UA on obesity was evaluated. The alterations of gut microbiota and metabolism related to obesity were evaluated by bioinformatic analysis. The results of the gut microbiota analysis showed that UA intervention could shift the Firmicutes to Bacteroidetes ratio at the phylum level and increase in the genera of Lactobacillus, Bacteroides, and Akkermansia. Additionally, metabolomics analysis showed that the beneficial influence of UA on obesity partly depended on amino acid metabolism. The current study demonstrated the roles of UA in the anti-obesity process, which depends in part on alterations in the gut microbiota and metabolism. Therefore, our findings highlight the potential therapeutic effect of UA on the improvement of diet-induced obesity in humans.

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TL;DR: For all types of surgery, the pattern of corneal sensation loss and recovery depends on the type, depth, and extent of incision because these influence the number of nerve fibers severed, and on the healing response of the patient.
Abstract: The cornea is densely innervated with free nerve endings to provide a high level of sensitivity to foreign bodies or noxious substances. They also provide trophic support to the tissues of the cornea and facilitate their repair and replacement. Any reduction in the function of the nerve endings through disease, contact lens wear, or surgery may lead to corneal disease, damage, or reduced healing. Assessment of the corneal nerve function can be made by the use of specialized instruments (aesthesiometers) that stimulate the corneal nerves using different modalities-mechanical, chemical, and thermal. Each modality assesses the function of a different cohort of corneal nerve type. Ocular surgery, particularly corneal surgery, can produce significant damage to the corneal innervation. However, for the majority of surgical procedures, corneal sensation eventually returns to preoperative levels, given enough time. The principal exceptions to this are penetrating keratoplasty, epikeratophakia, and cryo-keratomileusis, where sensation rarely returns to normal. For all types of surgery, the pattern of corneal sensation loss and recovery depends on the type, depth, and extent of incision because these influence the number of nerve fibers severed, and on the healing response of the patient.

17 citations

Journal Article
Wu W1, Liaoyuan Zeng, Peng Yy, Lu Xh, Li Cy, Wang Zc 
TL;DR: rhEGF had better promotive effect on corneal epithelial wound healing than the protein-free calf blood extract in the advanced phase (within 2 days) and both rhEGF and protein- free calfBlood extract were not found to promote.
Abstract: OBJECTIVE: This study was un - dertaken to investigate the effects of recombi - nant human epidermal growth factor (rhEGF) and protein-free calf blood extract on corneal wound healing and neovascularization. MATERIALS AND METHODS : An rabbit cen - tral corneal wound and neovascularization mod - el was established in rabbits. One eye of each group was chosen randomly for topical admin - istration of protein-free calf blood extract, rhEGF, or NS (physiological saline), and vari - ability in the area of corneal epithelial wound healing and neovascularization was observed. RESULTS : On days 1 and 2, the healing rate of corneal epithelium was various among the pro - tein-free calf blood extract group, rhEGF group and NS group (F = 6.475, p = 0.012). The healing rate of corneal epithelium in the rhEGF group was better than the protein-free calf blood ex - tract group ( p = 0.004) and NS group ( p = 0.041) on day 1. The corneal neovascularization area in the protein-free calf blood extract group was less than that of rhEGF group ( p = 0.04) and NS group ( p = 0.008) on day 18. CONCLUSIONS: rhEGF had better promotive effect on corneal epithelial wound healing than the protein-free calf blood extract in the advanced phase (within 2 days). Both rhEGF and protein- free calf blood extract were not found to promote the growth of CNV (corneal neovascularization).

8 citations

Journal ArticleDOI
TL;DR: The ideal method of post-laser-assisted in situ keratomileusis dry eye prevention is a meticulous peri-operational management plan, as opposed to post-operative management alone.
Abstract: Dry eye is the most common post-operative complication in patients who undergo laser-assisted in situ keratomileusis and other photorefractive procedures. Epidemiological studies have found that almost all patients experience some form of dry-eye-related discomfort in the post-operative period. This review seeks primarily to identify patient factors, which predispose to this complication, as well as outline the possible interventions clinicians can consider to avoid, prevent and treat this complication. Numerous pre-, intra- and post-operative guidelines are provided. The ideal method of post-laser-assisted in situ keratomileusis dry eye prevention is a meticulous peri-operative management plan, as opposed to post-operative management alone. Newer modalities of photorefractive surgery may have differing effects on the ocular surface.

6 citations

Journal ArticleDOI
TL;DR: The consensus covers a broad spectrum of commonly used ophthalmic solutions, provides recommendations of routine and enhanced medication on prevention and management of adverse reactions and complications related to the laser corneal refractive surgeries, and serves as a standard perioperative medication regimen for ophthalmologists.

2 citations