K
Kaifang Pang
Researcher at Baylor College of Medicine
Publications - 27
Citations - 916
Kaifang Pang is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Gene & Biology. The author has an hindex of 14, co-authored 23 publications receiving 679 citations. Previous affiliations of Kaifang Pang include Shanghai Jiao Tong University & Boston Children's Hospital.
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Journal ArticleDOI
Digital sorting of complex tissues for cell type-specific gene expression profiles
TL;DR: A Digital Sorting Algorithm for extracting cell-type specific gene expression profiles from mixed tissue samples that is unbiased and does not require prior knowledge of cell type frequencies is described.
Journal ArticleDOI
Human-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5p
Kihoon Han,Vincenzo A. Gennarino,Yoontae Lee,Yoontae Lee,Kaifang Pang,Kaifang Pang,Kazue Hashimoto-Torii,Sanaa Choufani,Chandrasekhar S. Raju,Michael C. Oldham,Rosanna Weksberg,Pasko Rakic,Zhandong Liu,Zhandong Liu,Huda Y. Zoghbi +14 more
TL;DR: This work shows that miR-483-5p, an intragenic microRNA of the imprinted IGF2, regulates MeCP2 levels through a human-specific binding site in the MECP2 long 3' UTR, and rescues abnormal dendritic spine phenotype of neurons overexpressing human Me CP2.
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Molecular pathway identification using biological network-regularized logistic models
Wen Zhang,Wen Zhang,Ying-Wooi Wan,Ying-Wooi Wan,Genevera I. Allen,Genevera I. Allen,Kaifang Pang,Kaifang Pang,Matthew L. Anderson,Zhandong Liu +9 more
TL;DR: Logistic regression with graph Laplacian regularization is an effective algorithm for identifying key pathways and modules associated with disease subtypes and will become more accurate and increasingly useful for mining transcriptomic, epi-genomic, and other types of genome wide association studies.
Journal ArticleDOI
Post-transcriptional regulation of SHANK3 expression by microRNAs related to multiple neuropsychiatric disorders.
Su Yeon Choi,Kaifang Pang,Kaifang Pang,Joo Yeon Kim,Jae Ryun Ryu,Hyojin Kang,Zhandong Liu,Zhandong Liu,Won Ki Kim,Woong Sun,Hyun Kim,Kihoon Han +11 more
TL;DR: This study provides new insight into the miRNA-mediated regulation of SHANK3 expression, and its potential implication in multiple neuropsychiatric disorders associated with altered SHank3 and miRNA expression profiles.
Journal ArticleDOI
Otud7a Knockout Mice Recapitulate Many Neurological Features of 15q13.3 Microdeletion Syndrome
Jiani Yin,Wu Chen,Eugene S. Chao,Eugene S. Chao,Sirena Soriano,Sirena Soriano,Li Wang,Li Wang,Wei Wang,Wei Wang,Steven E. Cummock,Huifang Tao,Huifang Tao,Kaifang Pang,Zhandong Liu,Zhandong Liu,Fred A. Pereira,Rodney C. Samaco,Huda Y. Zoghbi,Mingshan Xue,Christian P. Schaaf,Christian P. Schaaf +21 more
TL;DR: In this article, the authors identified OTU deubiquitinase 7A (Otud7a) as a critical gene responsible for many of the cardinal phenotypes associated with 15q133 microdeletion syndrome.