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Kailash C. Malhotra

Bio: Kailash C. Malhotra is an academic researcher from Indian Statistical Institute. The author has contributed to research in topics: Population & Dermatoglyphics. The author has an hindex of 20, co-authored 75 publications receiving 1058 citations. Previous affiliations of Kailash C. Malhotra include University of Hamburg & Savitribai Phule Pune University.


Papers
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TL;DR: In this paper, the shift from buffalo-keepers to goatherds to cultivators of increasingly marginal hill tracts, in the context of forest exploitation and malaria control, was examined.
Abstract: The Gavlis are a pastoral caste of the forested hill tracts of India 's Western Ghats region. This paper examines their shift under British colonial rule from buffalo-keepers to goatherds to cultivators of increasingly marginal hill tracts, the context of forest exploitation and malaria control as well as more recent dairy development programs of the Indian government. It concludes that if present trends continue Gavlis everywhere will follow the same progression, eventually becoming landless migrants.

29 citations

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TL;DR: Tests for agreement with Mendelian transmission frequencies were found to be very useful in discriminating between a non-Mendelian major effect and a major gene.
Abstract: Palmar pattern ridge counts were subjected to segregation analysis in an attempt to identify possible major gene effects on these dermatoglyphic traits. The phenotypes considered were total palmar pattern ridge count, and ridge counts for the right interdigital III and IV and left interdigital IV individual palmar areas (sample sizes were too small for the other palmar areas). Evidence of familial resemblance was found for all of the phenotypes studied, and initial evidence for a major effect was found for all but the right palm interdigital III ridge count. However, this initial evidence could be attributed to nongenetic effects in each case, including skewness in the trait distribution. Tests for agreement with Mendelian transmission frequencies were found to be very useful in discriminating between a non-Mendelian major effect and a major gene. We concluded against a major gene effect for any of these traits, and multifactorial inheritance remains a plausible alternative explanation for the familial resemblance.

28 citations

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TL;DR: Variations in allelle frequencies at 11 serological and biochemical loci among 21 endogamous Dhangar castes of Maharashtra, India, have been studied using Wright's FST statistic to find the distributional form of FST is explicable by random genetic drift at this early stage of differentiation of these caste groups.
Abstract: SummaryVariations in allelle frequencies at 11 serological and biochemical loci among 21 endogamous Dhangar castes of Maharashtra, India, have been studied using Wright's FST statistic. Gene differentiation among these castes is only about 4 per cent at these polymorphic loci. The distributional form of FST is explicable by random genetic drift at this early stage of differentiation of these caste groups. The empirical relationship between the average allele frequencies and the ratio of within to total gene diversity of the caste groups is also studied.

26 citations

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TL;DR: Comparison between the two groups on the basis of the markers studied showed that the Meiteis and Brahmins are very close to each other with respect to most of the loci except Gm, EsD and Hb, where significant statistical differences were found.
Abstract: Genetic polymorphism of 16 red-cell antigens, enzymes, serum proteins and Hb variants was investigated in 214 male and female individuals belonging to the Meiteis and a Brahmin caste group living in Imphal (Manipur, Northeast India). Ethno-historical records suggest that the Meiteis are of Mongoloid origin, while the original Brahmin settlers represent the easternmost part of the so-called Caucasoids. The markers studied are: A1A2BO, MNSs, Rh-system, Duffy, Diego; Gm, Km, Gc, Hp, Tf, Cp; Hb; aP, AK, EsD and LDH. The comparison between the two groups on the basis of the markers studied showed that the Meiteis and Brahmins are very close to each other with respect to most of the loci except Gm, EsD and Hb, where significant statistical differences were found.

26 citations

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TL;DR: The inbreeding levels among the Dhangars are high compared to other Maharashtrian groups, but substantially lower than in southern Dravidian speaking groups.
Abstract: Consanguinity is studied in a large sample of marriages among Dhangars of Maharashtra, India. The 22 endogamous castes included in the study show great variation in incidence, about an overall frequency of 26.4%. Matrilateral first cross-cousin unions are more frequency than patrilateral, and maternal uncle-niece nuions least frequent. Geograbhical differences are conspicuous, and all three types of consanguineous union show characteristic patterns; matrilateral unions increase in frequncy northwards, patrilateral and uncle-niece decrease northwards. The inbreeding levels among the Dhangars are high compared to other Maharashtrian groups, but substantially lower than in southern Dravidian speaking groups.

21 citations


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Journal ArticleDOI
TL;DR: These estimates can help countries and the international community gauge the need for appropriate diagnoses and genetic counselling to reduce the number of neonates affected by HbS and could be used for other inherited disorders.

838 citations

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TL;DR: The magnitude and variation in global, regional, and country-level prevalence rates of G6PD deficiency are of public health import, particularly in planning programs to improve neonatal health and in the distribution of various medications, especially antimalarial drugs, as G6 PD deficiency is most prevalent in malaria-endemic areas.
Abstract: Glucose-6-phosphate deficiency is the most prevalent enzyme deficiency, with an estimated 400 million people affected worldwide. This inherited deficiency causes neonatal hyperbilirubinemia and chronic hemolytic anemia. Although most affected individuals are asymptomatic, exposure to oxidative stressors such as certain drugs or infection, can elicit acute hemolysis. To characterize the global prevalence of G6PD deficiency, we conducted a systematic review of the G6PD deficiency literature, drawing studies from various databases, including MEDLINE/Pubmed and Biosis. Selected studies included cross-sectional and longitudinal studies published between 1960 and 2008. Additionally, meta-analytic procedures were employed to assess the degree of heterogeneity amongst prevalence estimates and, where appropriate, pool them. The searches yielded a total of 280 prevalence estimates, corresponding to 88 countries. The highest prevalence rates were reported among Sub-Saharan African countries, even after adjusting for assessment method. Meta-analysis revealed a high degree of heterogeneity for regional and global prevalence estimates. This heterogeneity in reported estimates appeared to be due to differences in G6PD deficiency assessment and diagnostic procedures. The magnitude and variation in global, regional, and country-level prevalence rates of G6PD deficiency are of public health import, particularly in planning programs to improve neonatal health and in the distribution of various medications, especially antimalarial drugs, as G6PD deficiency is most prevalent in malaria-endemic areas.

557 citations

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TL;DR: This work uses a comprehensive data assembly of HbS allele frequencies to generate the first evidence-based map of the worldwide distribution of the gene in a Bayesian geostatistical framework and finds geographical support for the malaria hypothesis globally.
Abstract: It has been 100 years since the first report of sickle haemoglobin (HbS). More than 50 years ago, it was suggested that the gene responsible for this disorder could reach high frequencies because of resistance conferred against malaria by the heterozygous carrier state. This traditional example of balancing selection is known as the 'malaria hypothesis'. However, the geographical relationship between the transmission intensity of malaria and associated HbS burden has never been formally investigated on a global scale. Here, we use a comprehensive data assembly of HbS allele frequencies to generate the first evidence-based map of the worldwide distribution of the gene in a Bayesian geostatistical framework. We compare this map with the pre-intervention distribution of malaria endemicity, using a novel geostatistical area-mean comparison. We find geographical support for the malaria hypothesis globally; the relationship is relatively strong in Africa but cannot be resolved in the Americas or in Asia.

472 citations